sodium nitroprusside dihydrate (CAS# 13755-38-9)

Thepa ea Lik'hemik'hale:

Foromo ea limolek'hule	C5H4FeN6Na2O3
'Misa oa Molar	297.95
Botenya	1.72
Ho qhibiliha ha Metsi	E qhibilihang ka metsing. Ethanol e qhibilihang hanyane.
Solubility	E qhibiliha ka metsing (400 g/l) ho 20 °C, le ethanol (e qhibilihang hanyenyane).
Ponahalo	Khalase e khubelu e tebileng
Matla a Khoheli a khethehileng	1.72
Mmala	Ruby e khubelu
Moedi wa ho pepeseha	ACGIH: TWA 1 mg/m3NIOSH: IDLH 25 mg/m3; TWA 1 mg/m3
Merck	14,8649
PH	5 (50g/l, H2O, 20℃)
Boemo ba polokelo	2-8°C
E hloahloa	Hygroscopic
MDL	MFCD00149192
Thepa ea 'Mele le ea Lik'hemik'hale	Phofo ea kristale e bofubelu bo sootho, e sa nkheng; E hlokang tatso.
Sebelisa	E sebelisoa e le reagent bakeng sa qeto ea aldehydes, acetone, sulfur dioxide, zinki, tšepe ea alkali, sulfide, joalo-joalo.
Thuto ea in vitro	Nitroprusside ea sodium ke vasodilator e sebetsang hantle. Nitroprusside ea sodium e na le phello e sebetsang ea vasodilatory ho arterioles le venules. Nitroprusside ea sodium e senyeha ho potoloha ho lokolla nitric oxide (NO). NO e kenyang guanylate cyclase ka har'a mesifa e boreleli ea methapo mme e eketsa tlhahiso ea intracellular cGMP. Qetellong sena se lebisa ho khatholoha ha mesifa e boreleli ea vascular, e fokotsang methapo ea mali. Nitroprusside ea sodium e fokotsa ho ata ha mesifa e boreleli ea methapo.
Thuto ea in vivo	Sodium nitroprusside (5 mg / kg) e le mofani oa nitric oxide e fokolitse haholo kotsi ea intestinal ischemia-reperfusion ho likhoto.

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Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Kotsi le Polokeho

Likhoutu tsa Kotsi	R25 – E chefo ha e koetsoe R26/27/28 – E chefo haholo ka ho hema, ka ho kopana le letlalo le haeba e koetsoe.
Tlhaloso ea Tšireletseho	S45 – Ha ho ka etsahala kotsi kapa ha o ikutlwa o sa phele hantle, batla keletso ya bongaka hanghang (bontsha leibole neng kapa neng ha ho kgoneha.) S36/37/39 - Apara liaparo tse loketseng tsa tšireletso, liatlana le tšireletso ea mahlo / sefahleho. S22 - U se ke ua hema lerole.
Li-ID tsa UN	UN 3288 6.1/PG 3
WGK Jeremane	3
RTECS	LJ8925000
LIKHOUTU FLUKA BRAND F	3
TSCA	Ee
Khoutu ea HS	28372000
Sehlopha sa Likotsi	6.1
Sehlopha sa ho paka	III
Chefo	LD50 ka molomo ho Mmutla: 99 mg/kg

13755-38-9 - Tlhaloso

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13755-38-9 - Selelekela

E qhibiliha ka metsing, e qhibiliha hanyenyane ka joala. Tharollo ea eona ea metsi ha e tsitsa 'me butle-butle e ka bola 'me ea fetoha e tala.

13755-38-9 - Boitsebiso ba Litšupiso

selelekela	sodium nitroprusside (formula ea molek'hule: Na2[Fe(CN)5NO]· 2H2O, lebitso la lik'hemik'hale: sodium nitroferricyanide dihydrate) ke vasodilator e sebetsang ka potlako le e khuts'oane, e sebelisoang ka bongaka bakeng sa khatello ea mali ea tšohanyetso joalo ka hypertension, hypertension encephalopathy, malignant hypertension, paroxysmal hypertension pele le ka morao ho opereishene ea pheochromocytoma, joalo-joalo, e ka sebelisoa bakeng sa hypotension e laolehileng nakong ea anesthesia ea ho buuoa.
phello	sodium nitroprusside ke vasodilator e matla e sebetsang ka potlako, e nang le phello e tobileng ho mesifa e boreleli ea arterial le venous, 'me e fokotsa peripheral vascular resistance ka ho atolosa methapo ea mali., Ho hlahisa phello ea antihypertensive. Ho hlajoa ha methapo ho ka boela ha fokotsa mojaro pele le ka morao ho pelo, ho ntlafatsa phallo ea pelo, le ho fokotsa reflux ea mali ha valve e sa koaloa, e le hore matšoao a ho hloleha ha pelo a ka imoloha.
lipontšo	1. e sebelisoa bakeng sa hypotension ea tšohanyetso ea maemo a tšohanyetso a khatello ea mali, joalo ka bothata ba khatello ea mali, khatello ea kelello ea mali, malignant hypertension, paroxysmal hypertension pele le ka mor'a opereishene ea pheochromocytoma, hape e ka sebelisoa bakeng sa hypotension e laoloang nakong ea anesthesia ea ho buuoa. 2. Bakeng sa ho hloleha ho matla ha pelo, ho kenyelletsa le edema e matla ea pulmonary. E boetse e sebelisoa bakeng sa ho hloleha ho matla ha pelo ho acute myocardial infarction kapa ha valve (mitral kapa aortic valve) e sa koaloa.
pharmacokinetics	fihla tlhōrōng ea khatello ea mali hang ka mor'a ho rotha ka methapo, 'me boemo ba eona bo itšetlehile ka lethal dose. Sehlahisoa sena se sebelisoa ke lisele tse khubelu tsa mali ho cyanide, cyanide sebeteng e kenngoa ka har'a thiocyanate, 'me metabolite ha e na mosebetsi oa vasodilating; cyanide e ka boela ea nka karolo ho metabolism ea vithamine B12. Sehlahisoa sena se sebetsa hang hang ka mor'a tsamaiso mme se fihla sehlohlolong sa ts'ebetso, 'me se boloka metsotso e 1 ~ 10 kamora ho emisa ho rotha ka methapo. Halofo ea bophelo ba bakuli ba nang le ts'ebetso e tloaelehileng ea renal ke matsatsi a 7 (e lekantsoeng ke thiocyanate), nako e telele ha ts'ebetso ea renal e fokola kapa sodium ea mali e le tlase haholo, 'me e ntšoa ke liphio.
Mokhoa oa maiketsetso oa ho lokisa	sodium nitroprusside, ho kenyelletsa le mehato e latelang: 1) Ho kopanya koporo nitroso ferrocyanide: ho eketsa palo e loketseng ea metsi a hloekisitsoeng ho qhaqha potassium nitroso-ferricyanide ka tanka ea crystallization, ho futhumatsa ho 70-80 ℃ ho e qhibiliha ka ho feletseng, 'me butle-butle eketsa koporo sulfate pentahydrate. tharollo ea metsi ka mor'a hore karabelo e lule e futhumetse metsotso e 30, centrifuge, kuku ea filthara ea centrifuged (copper nitroso ferricyanide) e kentsoe ka tanka ea crystallization. 2) Synthetic sodium nitroprusside (sodium nitronitroferricyanide): Lokisetsa tharollo ea metsi a sodium bicarbonate e tletseng metsi ho ea ka karolelano ea lijo, 'me butle-butle u e tlohele ka nitroso ferricyanide ka likhato tse 30-60 C. Ka mor'a karabelo, centrifuge, bokella filtrate le lotion. 3) Concentration and crystallization: Filtrate le lotion e bokelletsoeng li pompeloa ka tankeng ea mahloriso e hloekileng, 'me glacial acetic acid e eketsoa butle butle ho fihlela ho se na lipululana. Bulela pompo ea vacuum 'me u futhumale ho fihlela ho likhato tse 40-60, qala mahloriso, tsepamisa maikutlo ho palo e kholo ea pula ea likristale, koala valve ea mouoane, vacuum valve ho itokisetsa crystallization. 4) Ho omisoa ha Centrifugal: ka mor'a hore ho be le crystallization, supernatant e tlosoa, likristale li tsosoa ka tsela e ts'oanang 'me li centrifuged, kaka ea filthara e kenngoa ka poleiti ea tšepe e sa hloekang,' me sehlahisoa se fumanoa ka ho omisoa ka vacuum.
ts'ebetso ea likokoana-hloko	Sodium Nitroprusside ke vasodilator e matla e sebetsang ka ho itlela feela ho lokolla NO maling.
Sepheo	Boleng
Sebelisa	E sebelisoa e le reagent bakeng sa qeto ea aldehydes, ketone, sulfide, zinki, sulfur dioxide, joalo-joalo. E sebelisoa e le reagent bakeng sa qeto ea aldehydes, acetone, sulfur dioxide, zinki, tšepe ea alkali, sulfide, joalo-joalo. Li-vasodilators. Netefatso ea aldehydes le ketone, zinki, sulfur dioxide le alkali metal sulfide. Tlhahlobo ea Chromatic, tlhahlobo ea moroto.