(S)-(-)-1 2-Diaminopropane dihydrochloride (CAS# 19777-66-3)
Kotsi le Polokeho
| Likhoutu tsa Kotsi | R36/37/38 – Ho tena mahlo, tsamaiso ya ho hema le letlalo. R23/24/25 – E na le chefo ka ho hema, ho kopana le letlalo le haeba e koetsoe. |
| Tlhaloso ea Tšireletseho | S26 - Ha u kopana le mahlo, hlatsoa hang-hang ka metsi a mangata 'me u batle keletso ea bongaka. S36 - Apara liaparo tse loketseng tsa tšireletso. S45 – Ha ho ka etsahala kotsi kapa ha o ikutlwa o sa phele hantle, batla keletso ya bongaka hanghang (bontsha leibole neng kapa neng ha ho kgoneha.) S36/37/39 - Apara liaparo tse loketseng tsa tšireletso, liatlana le tšireletso ea mahlo / sefahleho. |
| WGK Jeremane | 3 |
| LIKHOUTU FLUKA BRAND F | 10-21 |
| Khoutu ea HS | 29212900 |
(S)-(-)-1 2-Diaminopropane dihydrochloride (CAS# 19777-66-3) Lintlha
| Kakaretso | (S) - (-) -diaminopropane dihydrochloride e ka sebelisoa e le motsoako oa meriana oa meriana, joalo ka ho lokisetsa Dexrazoxane, ke dextrorotatory enantiomer ea antitumor drug razoxane. Bakeng sa lithethefatsi tse sireletsang pelo, tleliniki bakeng sa Thibelo ea lithethefatsi tsa anticancer tsa anthracycline tse bakoang ke chefo ea pelo le leukemia ho bana ka lebaka la chemotherapy e bakoang ke tšenyo ea pelo, hangata e le motlatsi oa phekolo ea kankere. |
| Sebelisa | (S)-(-) -diaminopropane Dihydrochloride ke organic intermediate, e ka lokisoa ka ho itšoara ka D-(-)-tartaric acid le propylenediamine. Diamine e 'nile ea sebelisoa ha ho etsoa metsoako ea chiral imidazoline |
| tokisetso | ho lokisoa ha (S)-(-)-diaminopropane dihydrochloride: eketsa 30.0gD-(-)-tartaric acid le 8.0 ml metsi le g(±) -1, 2-propanediamine ka har'a flask ea reaction, hlohlelletsa ho qhibiliha, pholile, eketsa Dropwise, mocheso o ile oa phahamisoa ho reflux ka lihora tse 2 ka ho hlohlelletsa. Ho sisinyeha ho ile ha emisoa, 'me mocheso oa nyolohela ho 80 ° C. Ka hora e le 'ngoe. Joale, mocheso o ile oa theoleloa butle-butle ho mocheso oa kamore, ho huloa, le vacuum ea omisoa ho fumana 16.1g ea (S) -1, 2-propanediamine ditartrate. Kenya 16.1g ea (S) -1, 2-propanediamine ditartrate le ea metsi ho botlolo ea karabelo, qhala ka ho futhumatsa, ebe u eketsa tharollo ea 7.43g ea potassium chloride le 20ml ea metsi, motsoako o ile oa tsosoa ka 70 ° c. bakeng sa lihora tse 2. Ka mor'a ho pholile, sehatsetsi se ne se lumelloa ho ema bakeng sa kristale. Filtrate e ne e tlhotliloeng ka ho huloa 'me ea silafatsoa ho omella tlas'a khatello e fokotsehileng ho fana ka 84% G ea 'mala o mosehla (3), lihlahisoa 4.02,[α]20D =-°(C = 1%,H2O). |
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