Papaverine Hydrochloride(CAS#61-25-6)
| Likhoutu tsa Kotsi | R22 – E kotsi ha e kwetswe R34 – E baka ho cha R11 – E tuka Haholo |
| Tlhaloso ea Tšireletseho | S22 - U se ke ua hema lerole. S45 – Ha ho ka etsahala kotsi kapa ha o ikutlwa o sa phele hantle, batla keletso ya bongaka hanghang (bontsha leibole neng kapa neng ha ho kgoneha.) S36/37/39 - Apara liaparo tse loketseng tsa tšireletso, liatlana le tšireletso ea mahlo / sefahleho. S26 - Ha u kopana le mahlo, hlatsoa hang-hang ka metsi a mangata 'me u batle keletso ea bongaka. S16 - Ipoloke hole le mehloli ea mollo. |
| Li-ID tsa UN | UN 1544 6.1/PG 3 |
| WGK Jeremane | 1 |
| RTECS | NW8575000 |
| LIKHOUTU FLUKA BRAND F | 8 |
| TSCA | Ee |
| Khoutu ea HS | 29391900 |
| Sehlopha sa Likotsi | 6.1 |
| Sehlopha sa ho paka | III |
| Chefo | LD50 ka litoeba, likhoto (mg / kg): 27.5, 20 iv; 150, 370 sc (Levis) |
Papaverine Hydrochloride(CAS#61-25-6)
Papaverine hydrochloride, nomoro ea CAS 61-25-6, ke motsoako oa bohlokoa lefapheng la meriana.
Ho ea ka pono ea thepa ea lik'hemik'hale, ke mofuta oa hydrochloride oa papaverine, 'me sebopeho sa lik'hemik'hale se etsa qeto ea thepa ea eona. Tlhophiso ea liathomo le tlhophiso ea litlamo tsa lik'hemik'hale ka har'a sebopeho sa limolek'hule li e fa botsitso bo ikhethang le ho sebetsa hape. Ponahalo ka kakaretso e tšoeu ho isa ho phofo e khanyang ea kristale e mosehla, e loketseng ho sebetsa, ho boloka le ho tsamaisa lithethefatsi. Mabapi le solubility, e na le ho qhibiliha ka mokhoa o itekanetseng metsing, 'me maemo a fapaneng a acid-base le maemo a mocheso a tla ama litšobotsi tsa eona tsa ho qhibiliha, e leng tsa bohlokoa bo ka sehloohong bakeng sa ho etsoa ha lithethefatsi, nts'etsopele ea mefuta ea litekanyetso, le mokhoa oa ho etsa bonnete ba hore o lekana. ho hasana ha lithethefatsi ha ho etsoa liente le ho li lokisa ka molomo.
Mabapi le katleho ea pharmacological, Papaverine Hydrochloride ke ea sehlopha sa li-relaxation tsa mesifa e boreleli. Haholo-holo e sebetsa ka mesifa e boreleli ea methapo ea mali, pampitšana ea gastrointestinal, pampitšana ea biliary le likarolo tse ling, 'me e khothalletsa ho phomola ha mesifa e boreleli ka ho kena-kenana le mekhoa e kang ea intracellular calcium ion transport. Ka meriana, hangata e sebelisoa ho phekola ischemia e bakoang ke vasospasm, joalo ka hlooho le ho tsekela ho bakoang ke vasospasm ea boko, e ka ntlafatsang phallo ea mali ea sebakeng seo; E boetse e na le phello e kholo ea ho imolla bohloko ba ka mpeng le biliary colic e bakoang ke spasm ea mala, ho fokotsa bohloko ba bakuli.
Leha ho le joalo, joaloka meriana e mengata, ke habohlokoa hore u latele litaelo tsa ngaka ea hau ha u li sebelisa. Ka lebaka la mesebetsi e fapaneng ea 'mele le mafu a ka sehloohong a bakuli ka bomong, lingaka li hloka ho lekanya ka botlalo lilemo tsa mokuli, sebete le liphio, lithethefatsi tse ling tse nkiloeng le lintlha tse ling, le ho tseba ka nepo lethal dose, tsela ea tsamaiso le mokhoa oa meriana, kahoo e le ho etsa bonnete ba hore moriana o bolokehile ebile o sebetsa hantle, le ho thusa mokuli hore a hlaphoheloe. Ka tsoelopele ea lipatlisiso tsa mahlale, lipatlisiso le nts'etsopele ea mefuta e mecha ea litekanyetso le ho ntlafatsa litlhare tse kopaneng tse e potileng le tsona li ntse li futhumala.
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