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Nicorandil(CAS# 65141-46-0) Setšoantšo se Featured
  • Nicorandil(CAS# 65141-46-0) 1

Nicorandil(CAS# 65141-46-0)

Thepa ea Lik'hemik'hale:

Foromo ea limolek'hule C8H9N3O4
'Misa oa Molar 211.17
Botenya 1.4271 (khakanyo e fosahetseng)
Melting Point 92°C
Boling Point 350.85°C (khakanyo e boima)
Flash point 230°C
Solubility DMSO: >10 mg/mL. E qhibiliha ka methanol, ethanol, acetone kapa glacial acetic acid, e qhibiliha hanyenyane ka chloroform kapa metsing, hoo e batlang e sa qhibilihe ka har'a ether kapa benzene.
Khatello ea Mouoane 1.58E-08mmHg ho 25°C
Ponahalo Phofo ea kristale e tšoeu ho isa ho tšoeu
Mmala bosweu ho isa bosweu
Merck 14,6521
Boemo ba polokelo 2-8°C
Refractive Index 1.7400 (khakanyo)
MDL MFCD00186520
Thepa ea 'Mele le ea Lik'hemik'hale Phofo e tšoeu ea kristale, e sa nkheng kapa e nkhang hanyenyane, e baba. E qhibiliha ka methanol, ethanol, acetone kapa acetic acid, e qhibiliha hanyenyane ka chloroform kapa metsing, e 'maloa ha e qhibilihe ka har'a ether kapa benzene. Sebaka se qhibilihang ke 88.5-93.5 °c. Acute toxicity LD50 likhoto (mg/kg): 1200-1300 molomo, 800-1000 intravenous.
Sebelisa Bakeng sa thibelo ea lefu la pelo, angina pectoris
Thuto ea in vitro Nicorandil (100 mM) e ekelitse flavoprotein oxidation, empa ha ea ka ea ama membrane ea hona joale, ho khutlisetsa likanale tsa mitoK(ATP) le surfaceK(ATP) maemong a phahameng ho feta makhetlo a 10. Nicorandil e fokotsa lefu la sele ka mokhoa oa ischemic granulation, phello ea cardioprotective e koetsoeng ke mitoK(ATP) channel blocker 5-hydroxydecanoic acid empa eseng ka surfaceK(ATP). Phello ea blocker ea seteishene HMR1098. Nicorandil (100 mM) e thibela tahlehelo ea TUNEL positivity, cytochrome C translocation, caspase-3 activation, le mitochondrial membrane potential (Delta(Psi)(m)). Tlhahlobo ea lisele tse nang le fluorescence Delta(Psi)(m) -indicator, tetramethylrhodamine ethyl ester (TMRE) ka fluorescence activated cell sorter e bontšitse hore, nicorandil e thibela Delta(Psi)(m) depolarization ka mokhoa o itšetlehileng ka mahloriso (EC(50) ) hoo e ka bang 40 mM, saturation 100 mM). Liseleng tse peli tse fetisitsoeng, Nicolandil e ile ea kenya mocha oa ho lokisa o fokolang ka hare, o nang le glibenclamide-sensitive 80 pS K. Ka liseleng tsa HEK293T, Nicorandil ka ho khetheha o kenya mocha oa K(ATP) o nang le SUR2B. Nicorandil (100 mM) e ile ea thibela haholo palo ea lisele tse ka har'a li-nuclei tse ntle tsa TUNEL le ho eketsa mosebetsi oa 20 mM h2o2-induced caspase-3. Nicorandil e itšetlehile haholo ka ho thibela tahlehelo ea DeltaPsim e bakoang ke H2O2.
Thuto ea in vivo Nicorandil (2.5 mg / kg letsatsi le letsatsi, po) hammoho le Amlodipine (5.0 mg / kg letsatsi le leng le le leng, po) matsatsi a mararo a ts'ebetso a thibelitse haholo liphetoho le ho tsosolosa mosebetsi oa enzyme ho ea maemong a haufi le a likhoto tse tloaelehileng.

Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Matšoao a Kotsi Xn - E Kotsi
Likhoutu tsa Kotsi R22 – E kotsi ha e kwetswe
R41 – Kotsi ya tshenyo e kgolo mahlong
Tlhaloso ea Tšireletseho S26 - Ha u kopana le mahlo, hlatsoa hang-hang ka metsi a mangata 'me u batle keletso ea bongaka.
S39 - Apara ts'ireletso ea mahlo / sefahleho.
WGK Jeremane 3
RTECS US4667600
Khoutu ea HS 29333990
Chefo LD50 ka likhoto (mg / kg): 1200-1300 ka molomo; 800-1000 iv (Nagano)

 

Selelekela

Nicolandil, eo hape e tsejoang e le nicorandil amine, ke motsoako oa lintho tse phelang. Se latelang ke selelekela sa thepa, tšebeliso, tokiso le tlhaiso-leseling ea polokeho ea nicorandil:

 

Boleng:

- Nicorandil ke kristale e tiileng e se nang 'mala e qhibilihang ka metsing le ka har'a metsoako ea tlhaho.

- Ke motsoako oa alkaline o ka itšoarang ka li-acids ho hlahisa metsoako ea letsoai.

- Nicorandil e tsitsitse moeeng, empa e ka 'na ea bola ha e pepesehetse mocheso o phahameng.

 

Sebelisa:

- Nicolandil e ka sebelisoa hape ho kopantseng li-catalysts tsa organic synthesis, li-photosensitizers, jj.

 

Mokhoa:

- Nicolandil hangata e lokiselitsoe ke karabelo ea dimethylamine le metsoako ea 2-carbonyl.

- Karabelo e etsoa tlas'a maemo a alkaline 'me mokhoa oa ho futhumatsa o etsoa ka solvent e loketseng.

 

Lintlha tsa Tšireletseho:

- Nicorandil e batla e bolokehile bakeng sa batho tlasa maemo a akaretsang.

- Leha ho le joalo, tlhokomelo e lokela ho nkoa ho qoba ho kopana ka ho toba le mahlo, letlalo le tsamaiso ea ho hema.

- Apara lisebelisoa tse nepahetseng tsa ho itšireletsa (PPE) joalo ka likhalase tsa tšireletso, liatlana le lisebelisoa tsa ho hema.

- Ha u sebelisa kapa u boloka nicorandil, tlhokomelo e lokela ho nkoa ho qoba ho chesa le maemo a phahameng a mocheso.

 

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