Mmaraka o ntseng o hola oa meriana o lebisitse tsoelopeleng e kholo nts'etsopeleng ea li-derivatives tsa hydrazine, haholo-holo 1-benzyl-1-phenylhydrazine (CAS).614-31-3). Motsoako ona o hohetse tlhokomelo e ngata ka lebaka la ts'ebeliso ea ona libakeng tse fapaneng tsa kalafo joalo ka oncology le mafu a neurodegenerative.
1-Benzyl-1-phenylhydrazine ke k'hemik'hale e fapaneng e nang le thepa e ikhethang e etsang hore e be mokhethoa bakeng sa nts'etsopele ea lithethefatsi. Sebopeho sa eona se lumella liphetoho ho lihlopha tse sebetsang tse ntlafatsang katleho ea eona le ho fokotsa litla-morao. Bafuputsi ba ntse ba hlahloba karolo ea eona e le selelekela sa ho kopanya limolek'hule tse rarahaneng tse ka lebisang kalafong e ncha.
Liphuputso tsa morao-rao li bontšitse bokhoni ba motsoako oa ho thibela li-enzyme tse itseng tse amehang ho ata ha lisele tsa mofetše. Mokhoa ona oa ts'ebetso o etsa hore 1-benzyl-1-phenylhydrazine e be moemeli ea ts'episang khahlanong le mefuta e sa tšoaneng ea kankere, ho akarelletsa leukemia le lihlahala tse tiileng. Ho feta moo, ho ntse ho ithutoa litšobotsi tsa eona tsa methapo ea kutlo, 'me liphetho tsa pele li fana ka maikutlo a hore e ka thusa ho fokotsa litlamorao tsa mafu a neurodegenerative joalo ka Alzheimer's le Parkinson.
Indasteri ea meriana e ntse e bona keketseho ea thahasello ho li-derivatives tsa hydrazine ka lebaka la tlhoko ea mekhoa e mecha ea kalafo ho sebetsana le litlhoko tse sa fihlelleheng tsa bongaka. Likhamphani li tsetela ho R&D ho hlahloba bokhoni bo felletseng ba 1-benzyl-1-phenylhydrazine, ka liteko tse ngata tsa kliniki tse lebelletsoeng ho qala likhoeling tse tlang.
Ha 'maraka oa litlhare tse khethehileng o ntse o hola, ho kopanngoa ha metsoako e kang 1-benzyl-1-phenylhydrazine ho li-regimens tsa kalafo ho na le monyetla oa ho fetola likhetho tsa kalafo. Batho ba amehang indastering ea meriana ba shebile ka hloko lintlafatso tsena, 'me katleho ea k'hemistri ea hydrazine e lebeletsoe ho ntlafatsa haholo tlhokomelo ea mokuli le liphello tsa phekolo.
Ka bokhutšoanyane, lipatlisiso tse ntseng li tsoela pele ho 1-benzyl-1-phenylhydrazine li bonts'a sebopeho se matla sa 'maraka oa meriana, moo boqapi le tšebelisano' moho e leng senotlolo sa ho rarolla mathata a bophelo bo botle ba lefats'e.
Nako ea poso: Dec-01-2024