Mmaraka oa Europe oa meriana o ntse o le maemong a liphetoho tse kholo, o susumetsoa ke tlhokahalo e ntseng e hola ea liphekolo tse ncha le nts'etsopele e tsoelang pele ea lits'ebetso tsa tlhahiso ea lithethefatsi. E 'ngoe ea libapali tsa bohlokoa lefapheng lena ke 2-aminobenzonitrile, e leng setsi sa bohlokoa sa meriana se seng se hohetse tlhokomelo e ngata ka lebaka la karolo ea eona ho kopanngoeng ha lapatinib, e leng phekolo e lebisitsoeng e sebelisoang haholo-holo ho phekola mofetše oa matsoele.
2-Aminobenzonitrile, sekhetho sa lik'hemik'hale1885-29-6, ke motsoako o nkhang hamonate oo e leng oona motheo oa ho haha tlhahiso ea mefuta e sa tšoaneng ea meriana. Lik'hemik'hale tsa eona tse ikhethang tsa lik'hemik'hale li etsa hore e be karolo ea bohlokoa ea bohareng ha ho etsoa lapatinib, e leng dual tyrosine kinase inhibitor e lebisang tlhokomelo ea epidermal growth factor receptor (EGFR) le human epidermal growth factor receptor 2 (HER2). Mokhoa ona oa ts'ebetso o molemo haholo ho bakuli ba nang le mofetše oa matsoele o nang le HER2, o fana ka mokhoa o lebisitsoeng oa kalafo o fokotsang tšenyo ea lisele tse phetseng hantle ha e bapisoa le chemotherapy ea setso.
Lilemong tsa morao tjena, tlhoko ea lapatinib e eketsehile ka sekhahla se ntseng se eketseha sa mofetše oa matsoele le tlhokomeliso e ntseng e eketseha ea bohlokoa ba meriana e etselitsoeng motho ka mong. Ka lebaka leo, 'maraka oa li-intermediate tsa meriana, ho kenyelletsa le 2-aminobenzonitrile, o ntse o eketseha ka potlako. Likhamphani tsa meriana tsa Europe li tsetela haholo lipatlisisong le nts'etsopeleng ho ntlafatsa ts'ebetso ea tlhahiso ea lapatinib, e leng eona e tsamaisang tlhokahalo ea li-intermediate tsa boleng bo holimo.
E 'ngoe ea lintlha tsa bohlokoa tse susumetsang 'maraka oa Europe oa 2-aminobenzonitrile ke tikoloho e thata ea taolo ea tikoloho. European Medicines Agency (EMA) e behile litataiso tse tiileng bakeng sa tlhahiso le taolo ea boleng ba li-intermediate tsa meriana, ho netefatsa hore ke litekanyetso tse phahameng feela tse fihlelletsoeng. Moralo ona oa taolo ha o sireletse tšireletseho ea mokuli feela empa o boetse o khothalletsa mekhoa e mecha ka har'a indasteri ha lik'hamphani li ntse li leka ho lumellana le litekanyetso tsena ha li ntse li hlahisa mekhoa e mecha le e ntlafalitsoeng ea maiketsetso.
Ho feta moo, 'maraka oa Europe o tšoauoa ka tšekamelo e ntseng e hola ea ts'ebetso le k'hemistri e tala. Baetsi ba meriana ba ntse ba batla mekhoa e metle ea tikoloho ho hlahisa li-intermediate tse kang 2-aminobenzonitrile. Phetoho ena e tsamaisoa ke khatello ea taolo le tlhokahalo ea bareki bakeng sa mekhoa e tsitsitseng. Likhamphani li ntse li hlahloba litsela tse ling tsa ho kopanya ho fokotsa litšila le ho fokotsa tšusumetso ea tikoloho mesebetsing ea tsona, ho latela lipheo tse pharaletseng tsa European Green Deal.
Ntle le botsitso, 'maraka oa Europe oa meriana o boetse o tobana le leqhubu la tsoelopele ea theknoloji. Ho kopanngoa ha bohlale ba maiketsetso (AI) le ho ithuta ka mochine ts'ebetsong ea ntlafatso ea lithethefatsi ho fetola tsela eo li-intermediate tsa meriana li hlahisoang ka eona. Mahlale ana a thusa lik'hamphani ho ntlafatsa litsela tsa tsona tsa maiketsetso, ho fokotsa litšenyehelo tsa tlhahiso, le ho potlakisa nako ea ho rekisa lithethefatsi tsa bohlokoa tse kang lapatinib.
Ha 'maraka oa meriana oa Europe o ntse o tsoela pele ho hola, karolo ea batho ba lipakeng joalo ka 2-aminobenzonitrile e tla lula e le bohlokoa. Patlisiso e tsoelang pele mabapi le lits'ebetso tse ncha le mekhoa ea maiketsetso e kanna ea tsamaisa boqapi bo eketsehileng tlhahisong ea lapatinib le liphekolo tse ling tse lebisitsoeng. Sena le sona se tla ntlafatsa khetho ea kalafo bakeng sa bakuli le ho kenya letsoho kholong e akaretsang ea indasteri ea meriana ea Europe.
Ka bokhuts'oane, mateano a ho latela melao, botsitso, le mahlale a mahlale a theha bokamoso ba 'maraka oa meriana oa Europe. Ha tlhokahalo ea lapatinib le li-intermediate tsa eona, tse kang 2-aminobenzonitrile, e ntse e eketseha, ba amehang ho pholletsa le indasteri ba tlameha ho ikamahanya le mekhoa ena ho lula ba le tlhōlisano le ho finyella litlhoko tse tsoelang pele tsa bakuli. Bokamoso ba li-intermediate tsa meriana bo khanyang, 'me 2-aminobenzonitrile e ka pele ho sebaka sena se matla.
Nako ea poso: Dec-12-2024