Tlhokahalo ea indasteri ea meriana ea li-intermediate tsa boleng bo holimo, tse bohlokoa bakeng sa ho kopanya metsoako e fapaneng ea kalafo, e eketsehile haholo lilemong tsa morao tjena. Har'a tsena tse lipakeng, 3,5-di-tert-butyl-4-hydroxybenzaldehyde (CAS#1620-98-0) e se e le sebapali sa bohlokoa limmarakeng tsa US le Europe. E tsebahala ka thepa ea eona e ikhethang ea lik'hemik'hale le ho feto-fetoha ha maemo, k'hemik'hale ena e ntse e sebelisoa ka ho eketsehileng tlhahiso ea meriana, agrochemicals le lik'hemik'hale tse khethehileng.
3,5-di-tert-butyl-4-hydroxybenzaldehyde e tsejoa haholo-holo bakeng sa karolo ea eona e le setsi sa meriana. Ke thepa ea mantlha bakeng sa ho kopanya metsoako e fapaneng e sebetsang ea meriana (APIs), haholo-holo e sebelisetsoang ho alafa mafu a sa foleng a kang mofetše, lefu la pelo le metabolic syndrome. Bokhoni ba motsoako oa ho matlafatsa ts'ebetso le botsitso ba litlhare tsa meriana bo entse hore e be motsoako o batloang haholo ho baetsi ba lithethefatsi.
Mmaraka oa US 3,5-di-tert-butyl-4-hydroxybenzaldehyde o bile le kholo e matla, e susumetsoang ke matsete a ntseng a eketseha mesebetsing ea lipatlisiso le nts'etsopele (R&D) ke lik'hamphani tsa meriana. Keketseho ea mafu a sa foleng le tlhokahalo e latelang ea liphekolo tse ncha li tsoetse pele tlhokahalo ea li-intermediate tsa boleng bo holimo. Ho feta moo, indasteri ea meriana e hōlileng tsebong le tikoloho e ntle ea taolo United States li tlatselitse ho tumang ha motsoako ona.
Europe, boemo bo tšoana, le linaha tse kang Jeremane, Fora le UK tse etellang pele tšebeliso ea 3,5-di-tert-butyl-4-hydroxybenzaldehyde. 'Maraka oa meriana oa Europe o khetholloa ka litekanyetso le melaoana e tiileng ea boleng, e khothalletsang bahlahisi ho batla mehloli e tšepahalang ea li-intermediate tsa meriana. Motsoako ona o latela litataiso tsa European Medicines Agency (EMA), e leng se etsang hore e be khetho e khahlang bakeng sa lik'hamphani tse batlang ho ntlafatsa li-portfolio tsa lihlahisoa tsa tsona.
Ho feta moo, ho tsepamisa maikutlo ho ntseng ho hola mabapi le ts'ebetso le litloaelo tsa k'hemistri e tala United States le Europe ho lebisitse phetohong ea ho fumana lik'hemik'hale tse mahareng. Hona joale bahlahisi ba etelletsa pele barekisi ba khomarelang litloaelo tse baballang tikoloho, e leng ho eketsang tlhoko ea 3,5-di-tert-butyl-4-hydroxybenzaldehyde. Likhamphani tse ka bonts'ang boitlamo mekhoeng ea tlhahiso ea moshoelella li ka fumana molemo oa tlholisano 'marakeng.
Phepelo ea 3,5-di-tert-butyl-4-hydroxybenzaldehyde le eona e ntse e tsoela pele, 'me bahlahisi ba ntse ba lekola maano a macha a ho etsa bonnete ba hore ho na le phepelo e tsitsitseng ea karolo ena ea bohlokoa. Litšebelisano lipakeng tsa baetsi ba lik'hemik'hale le lik'hamphani tsa meriana li ntse li ata haholo kaha ka bobeli li batla ho ntlafatsa ts'ebetso ea tlhahiso le ho fokotsa litšenyehelo. Mokhoa ona o lebelletsoe ho tsoela pele ha tlhoko ea li-intermediate tsa boleng bo holimo e ntse e le matla.
Qetellong, 'maraka oa 3,5-di-tert-butyl-4-hydroxybenzaldehyde e le setsi sa meriana o lebelletsoe ho hola haholo United States le Europe. Ho feto-fetoha ha kompone, ho ipapisa le maemo a taolo le ho ikamahanya le lipheo tsa nts'etsopele ea moshoelella ho etsa hore e be letlotlo la bohlokoa indastering ea meriana. Ha tlhoko ea liphekolo tse ncha e ntse e eketseha, bohlokoa ba li-intermediate tse tšepahalang le tsa boleng bo holimo joalo ka 3,5-di-tert-butyl-4-hydroxybenzaldehyde li tla eketseha, ho theha maemo a kamoso a tlhahiso ea meriana libakeng tsena.
Nako ea poso: Oct-30-2024