N-Boc-N'-tosyl-D-histidine (CAS# 69541-68-0)
Selelekela
Boc-D-His(Tos)-OH(Boc-D-His(Tos)-OH) ke ntho ea lik'hemik'hale e nang le litšobotsi tse latelang:
Tlhaho:
1. Ponahalo: e tšoeu e tiileng
2. foromo ea molek'hule: C21H25N3O6S
3. boima ba molek'hule: 443,51
4. Sebaka se qhibilihang: hoo e ka bang 110-115°C
Sebelisa:
Boc-D-His(Tos) -OH e atisa ho sebelisoa ho organic synthesis e le sehlopha se sireletsang bakeng sa D-histidine (D-His). Lisebelisoa tsa eona tsa mantlha li kenyelletsa:
1. Ha ho etsoa polypeptide, e sebelisetsoa ho etsa tatellano ea polypeptide e nang le sehlopha se sireletsang sa D-histidine.
2. E sebelisoa e le setsi sa lipakeng lefapheng la k'hemistri ea meriana bakeng sa ho kopanya metsoako ea likokoana-hloko e sebetsang.
3. Moralo le tlhophiso ea metsoako ea mokhethoa oa lithethefatsi lipatlisisong.
Mokhoa oa ho itokisa:
Tokisetso ea Boc-D-His(Tos)-OH hangata e etsoa ka mehato e latelang:
1. D-histidine (D-His) e ile ea itšoara ka p-toluenesulfonyl chloride (p-toluenesulfonyl chloride) ho fana ka D-histidine p-toluenesulfonyl (D-His-Tos).
2. Tlas'a maemo a alkaline, D-His-Tos e sebetsanoa le n-butoxycarbonylhydrazine (tert-butyloxycarbonylhydrazide) ho hlahisa Boc-D-His(Tos) -OH.
Lintlha tsa Tšireletseho:
Tekolo ea polokeho ea Boc-D-His(Tos)-OH e na le moeli, empa joalo ka ntho ea lik'hemik'hale, lintlha tse latelang tsa polokeho li lokela ho hlokomeloa:
1. Qoba ho inhalation, ho kopana le letlalo le mahlo. Apara lisebelisoa tse loketseng tsa ho itšireletsa, tse kang liatlana le likhalase.
2. Mekhoa e metle ea laboratori e lokela ho lateloa nakong ea tšebeliso le maemo a matle a moea a lokela ho netefatsoa.
3. Boloka ka sejaneng se tiisitsoeng, hole le mollo le oxidant.
4. Latela melao le litataiso tse amehang nakong ea ts'ebetso.
Ha u sebelisa Boc-D-His(Tos)-OH, ka kopo etsa bonnete ba hore u latela melao e amehang ea polokeho ea laboratori le litaelo tsa ts'ebetso, 'me u boloke le ho tšoara lik'hemik'hale ka nepo. Haeba ho hlokahala, ho kgothaletswa ho sebetsa tlas'a tataiso ea litsebi.
