Mitotan (CAS# 53-19-0)

Thepa ea Lik'hemik'hale:

Foromo ea limolek'hule	C14H10Cl4
'Misa oa Molar	320.04
Botenya	1.3118 (khakanyo e fosahetseng)
Melting Point	77-78°C(lebone)
Boling Point	405.59°C (khakanyo e boima)
Ho qhibiliha ha Metsi	<0.1 g/100 mL ka 24 ºC
Solubility	DMSO: soluble20mg/mL, e hlakile
Ponahalo	phofo
Mmala	bosoeu ho isa ho beige
Merck	13,6237 / 13,6237
BRN	2056007
Boemo ba polokelo	Boemo bo sa tsitsang, Mocheso oa Kamore
Refractive Index	1.6000 (khakanyo)
Thepa ea 'Mele le ea Lik'hemik'hale	Sebaka sa ho qhibiliha ke 76-78°C qhibilihang ka metsing <0.1g/100 mL ka 24°C
Sebelisa	Sehlahisoa sena ke sa lipatlisiso tsa mahlale feela 'me se ke ke sa sebelisetsoa merero e meng.
Thuto ea in vitro	Moleng oa sele ea mouse TalphaT1, Mitotane e thibela polelo le secretion ea TSH, e thibela karabo ea TSH ho TRH, 'me e fokotsa matla a lisele,' me e etsa hore apoptosis e be teng. Liseleng tsa pituitary TSH-secreting mouse, Mitotane ha e kena-kenane le hormone ea qoqotho, empa ka ho toba e fokotsa mosebetsi oa sekhukhu le ho sebetsa ha sele. Mitotane e baka adrenal cortical necrosis, tšenyo ea membrane ea mitochondrial, le ho tlama ho ke keng ha khutlisoa ho protheine CYP. Mitotane (10-40 μm) e thibelitse secretion ea cortisol ea basal le cAMP empa ha ea ka ea baka lefu la sele. Mitotane e bontšitse liphello tse thibelang liprotheine tsa basal Star le P450scc. Mitotane (40 μm) e fokolitse haholo litekanyetso tsa mRNA tsa Star, CYP11A1 le cyp21. Mitotane (40 μm) e batla e se na thuso ka ho feletseng ho kenngoa ha STAR, CYP11A1, CYP17, le CYP21 mRNA ka adenosine 8-bromo-cyclic phosphate. Karolong ea S ea lisele tsa H295R, motsoako oa Mitotane le gemcitabine o bontšitse ho hanyetsa le ho kena-kenana le thibelo ea gemcitabine-mediated inhibition in cell cycle.
Thuto ea in vivo	Likhotong, Mitotane (60 mg / kg) e fokolitse haholo adrenal mitochondrial le microsomal "P-450" le liprotheine tsa microsomal ka 34%,55% le 35%.

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Matšoao a Kotsi	Xn - E Kotsi
Likhoutu tsa Kotsi	40 - Bopaki bo fokolang ba phello ea kankere
Tlhaloso ea Tšireletseho	36/37 - Apara liaparo tse loketseng tsa tšireletso le liatlana.
Li-ID tsa UN	3249
WGK Jeremane	3
RTECS	KH7880000
Khoutu ea HS	2903990002
Sehlopha sa Likotsi	6.1(b)
Sehlopha sa ho paka	III

Selelekela

Mitotane ke motsoako oa tlhaho o nang le lebitso la lik'hemik'hale N,N'-methylene diphenylamine. Se latelang ke selelekela sa thepa, tšebeliso, mekhoa ea ho lokisa le tlhahisoleseding ea polokeho ea mitotane:

Boleng:

- Mitotane ke kristale e tiileng e se nang 'mala e qhibilihang ka har'a metsoako ea tlhaho e kang ethanol, ether le chloroform.

- Mitotane e na le monko o matla o hlabang.

Sebelisa:

- Mitotane e sebelisoa haholo-holo bakeng sa ho kopanya karabelo ho organic synthesis 'me hangata e sebelisoa e le reagent le catalyst.

- E ka nka karolo liketsong tse fapaneng tsa lik'hemik'hale, joalo ka ho kopanngoa ha alkynes, alkylation ea metsoako e nkhang hamonate, joalo-joalo.

Mokhoa:

- Mitotane e ka etsoa ka karabelo ea mehato e 'meli. Formaldehyde e sebetsana le diphenylamine tlas'a maemo a alkaline ho theha N-formaldehyde diphenylamine. Joale, ka pyrolysis kapa karabelo ea oxidation e laoloang, e fetoloa mitotane.

Lintlha tsa Tšireletseho:

- Mitotane ke motsoako o halefisang 'me ha oa lokela ho kopana ka ho toba le letlalo le mahlo. Thepa e loketseng ea tšireletso e kang liatlana, likhalase le liaparo tse sireletsang li lokela ho apesoa ha ho sebetsoa.

- Ha u boloka le ho tšoara, hlokomela ho tiisa le ho sireletsa leseli ho qoba ho kopana le moea le mongobo.

- Mitotane e bola ka mocheso o phahameng ho hlahisa likhase tse chefo, ho qoba ho futhumatsa kapa ho kopana le lintho tse ling tse tukang.

- Sheba melao ea lehae 'me u latele mekhoa e sebetsang ea ts'ireletso ha u e lahla.

E fetileng: 4-(4-methoxyphenyl) -1-butanol (CAS# 52244-70-9)

E 'ngoe: 2-Chloro-5-aminopyridine (CAS# 5350-93-6)

Ngola molaetsa wa hao mona mme o re romele wona