Methyl 2-cyanoisonicotinate (CAS# 94413-64-6)
Kotsi le Polokeho
| Sehlopha sa Likotsi | 6.1 |
Mokhoa oa tlhahiso
motsoako o reretsoeng o ne o lokiselitsoe ke oxidation, amidation le dehydration le methyl 2-methyl 4-pyridinecarboxylate (2) e le thepa ea ho qala. sebopeho sa eona se tiisitsoe ke 1H NMR le MS, 'me kakaretso ea lihlahisoa e ne e le 53.0%. Liphello tsa karo-karolelano ea lijo, mocheso oa crystallization, nako ea ho itšoara le lintlha tse ling ho sehlahisoa li ile tsa ithutoa ke liteko tsa ntho e le 'ngoe,' me maemo a ts'ebetso a ile a ntlafatsoa: n (2): n (potassium permanganate) = 1.0: 2.5, mocheso oa crystallization 0 ~5 ℃;n (methyl 2-carboxyl -4-pyridinecarboxylate):n (sulfoxide) = 1.0:1.4, karabelo; karabelo ea dehydration e khetha trifluoroacetic anhydride-triethylamine system e le dehydrating agent. Ts'ebetso e bonolo ho e sebetsa, maemo a karabelo a bonolo, a bonolo ho phahamisa tlhahiso, 'me a na le boleng bo botle ba ts'ebeliso.
Sebelisa
Tobisostat e sebelisoa ho phekola hyperuricemia e sa foleng ea gout. Ha ho bapisoa le lithethefatsi tsa setso allopurinol (purine analog), e ke ke ea ama purine le pyridine metabolism le mosebetsi oa enzyme, 'me e fokotsa uric acid Phello e matla, ha ho na tsamaiso e ngata e pheta-phetoang e hlokahalang,' me tšireletseho e molemo. Methyl 2-cyano-4-pyridine carboxylate ke thepa ea bohlokoa e tala bakeng sa motsoako oa Tobiso.
