L-Pyroglutamic acid CAS 98-79-3
Kotsi le Polokeho
| Matšoao a Kotsi | Xi - Ea halefisang |
| Likhoutu tsa Kotsi | 36/37/38 - Ho halefisa mahlo, tsamaiso ea ho hema le letlalo. |
| Tlhaloso ea Tšireletseho | S26 - Ha u kopana le mahlo, hlatsoa hang-hang ka metsi a mangata 'me u batle keletso ea bongaka. S36 - Apara liaparo tse loketseng tsa tšireletso. S37/39 - Apara liatlana tse loketseng le tšireletso ea mahlo / sefahleho |
| WGK Jeremane | 3 |
| RTECS | TW3710000 |
| LIKHOUTU FLUKA BRAND F | 21 |
| TSCA | Ee |
| Khoutu ea HS | 29337900 |
| Selelekela | pyroglutamic acid ke 5-oxyproline. E thehoa ka ho felloa ke metsi pakeng tsa sehlopha sa α-NH2 le sehlopha sa γ-hydroxyl sa glutamic acid ho theha bond ea molecular lactam; E ka boela ea thehoa ka ho lahleheloa ke sehlopha sa Amido ka molek'hule ea glutamine. Haeba khaello ea glutathione synthetase e ka baka pyroglutamemia, letoto la matšoao a kliniki. Pyroglutamemia ke bothata ba metabolism ea organic acid bo bakoang ke khaello ea glutathione synthetase. Liponahatso tsa bongaka tsa tsoalo 12 ~ lihora tse 24 tsa ho qala, tsoelo-pele ea hemolysis, jaundice, e sa foleng Metabolic Acidosis, mathata a kelello, joalo-joalo; Moroto o na le pyroglutamic acid, lactic acid, Alpha deoxy4 glycoloacetic acid lipid. Kalafo, symptomatic, ela hloko ho fetola lijo ka mor'a lilemo. |
| thepa | L-pyroglutamic acid, e tsejoang hape e le L-pyroglutamic acid, L-pyroglutamic acid. Ho tsoa motsoakong oa ethanol le petroleum ether ka har'a pula e se nang mebala ea orthorhombic double cone Crystal, ntlha e qhibilihang ea 162~163 ℃. E qhibiliha ka metsing, joala, acetone le acetic acid, ethyl acetate-soluble, insolble in ether. Potoloho e khethehileng ea optical -11.9 °(c = 2,H2O). |
| Likarolo le lisebelisoa | letlalong la motho le na le ts'ebetso ea moisturizing ea lintho tse qhibilihang ka metsing-moisturizing factor ea tlhaho, sebopeho sa eona ke hoo e ka bang amino acid (e nang le 40%), pyroglutamic acid (e nang le 12%), matsoai a inorganic (Na, K, Ca, Mg, joalo-joalo. e nang le 18.5%), le metsoako e meng ea manyolo (e nang le 29.5%). Ka hona, pyroglutamic acid ke e 'ngoe ea likarolo tse ka sehloohong tsa letlalo la tlhaho,' me matla a eona a mongobo a feta hōle a glycerol le propylene glycol. 'Me e seng chefo, ha e na tšusumetso, ke Tlhokomelo ea Letlalo ea sejoale-joale, litlolo tsa Tlhokomelo ea Moriri lisebelisuoa tse ntle tse tala. Pyroglutamic acid e boetse e na le phello e thibelang ts'ebetso ea tyrosine oxidase, ka hona e thibela ho kenngoa ha "melanoid" letlalong, le nang le phello e soeufatsang letlalong. E na le phello e nolofatsang letlalong, e ka sebelisoa bakeng sa litlolo tsa lipekere. Ntle le ts'ebeliso ea litlolo, L-pyroglutamic acid e ka boela ea hlahisa lihlahisoa tse nang le metsoako e meng ea lintho tse phelang, tse nang le liphello tse khethehileng mosebetsing oa holim'a metsi, phello e hlakileng le e khanyang, joalo-joalo E ka boela ea sebelisoa e le surfactant bakeng sa li-detergents; Li-reagents tsa lik'hemik'hale bakeng sa tharollo ea li-amine tsa racemic; Li-intermediates tse phelang. |
| mokhoa oa ho lokisetsa | L-pyroglutamic acid e thehoa ka ho tlosa metsotso e le 'ngoe ea metsi ho molek'hule ea L-glutamic acid,' me mokhoa oa eona oa ho itokisa o bonolo, mehato ea bohlokoa ke ho laola mocheso le nako ea ho nosetsa. (1) 500g ea L-glutamic acid e ile ea kenngoa bekeng ea 100 ml, 'me beakere e ne e futhumatsoa ka ho hlapa ka oli,' me mocheso oa nyolohela ho 145 ho ea ho 150 ° C., 'me mocheso o bolokoa metsotso e 45 bakeng sa ho felloa ke metsi. karabelo. Tharollo e senyehileng e ne e le Tan. (2) ka mor'a hore ho phethoe karabelo ea ho felloa ke metsi, tharollo e tšeloa ka metsing a belang ka boholo ba hoo e ka bang 350, 'me tharollo e ile ea qhibiliha ka ho feletseng metsing. Kamora ho pholile ho isa ho 40 ho isa ho 50 ° C., ho ile ha eketsoa palo e loketseng ea khabone e kentsoeng bakeng sa decoloration (e phetoa habeli). Tharollo e bonaletsang e se nang mebala e ile ea fumanoa. (3) ha tharollo e sa bonahaleng e se nang mebala e lokiselitsoeng mohatong oa (2) e futhumatsoa ka ho toba 'me e fetoha mouoane ho fokotsa molumo ho hoo e ka bang halofo, retelehela sebakeng sa ho hlapa metsi 'me u tsoele pele ho tsepamisa mohopolo ho hoo e ka bang 1/3, u ka emisa ho futhumatsa; le ka bateng ea metsi a chesang ho fokotsa kristale, lihora tse 10 ho isa ho tse 20 ka mor'a ho lokisoa ha likristale tse se nang mebala tsa prismatic. Palo ea L-pyroglutamic acid ka litlolo e itšetlehile ka sebopeho. Sehlahisoa sena se ka boela sa sebelisoa ho litlolo ka mokhoa oa 50% ea tharollo e tsepamisitsoeng. |
| asiti ea glutamic | glutamic acid ke amino acid e etsang protheine, e na le ketane ea mahlakoreng a ionized, mme e bonts'a hydrotropism. Asiti ea glutamic e kotsing ea ho ba cyclization ho pyrrolidone carboxylic acid, I.e., pyroglutamic acid. glutamic acid e phahame haholo liprotheine tsohle tsa lijo-thollo, e fana ka alpha-ketoglutarate ka potoloho ea tricarboxylic acid. Alpha ketoglutaric acid e ka etsoa ka ho toba ho tloha ho ammonia tlas'a catalysis ea glutamate dehydrogenase le NADPH (coenzyme II), hape e ka hlahisoa ke aspartate aminotransferase kapa alanine aminotransferase, glutamic acid e hlahisoa ke transamination ea aspartic acid kapa alanine; Ho phaella moo, asiti ea glutamic e ka fetoloa ka mokhoa o fetohang ka proline le ornithine (ho tloha ho arginine), ka ho latellana. Ka hona, glutamate ke amino acid e seng ea bohlokoa. Ha glutamic acid e tlosoa tlas'a catalysis ea glutamate dehydrogenase le NAD (coenzyme I) kapa e fetisetsoa ho tsoa sehlopheng sa amino tlas'a catalysis ea aspartate aminotransferase kapa alanine aminotransferase ho hlahisa alpha ketoglutarate, e kena potolohong ea tricarboxylic acid 'me e hlahisa tsoekere ka gluconeogenic pathway, kahoo glutamic acid ke glycogenic amino acid ea bohlokoa. glutamic acid ka lisele tse fapaneng (tse kang mesifa, sebete, boko, joalo-joalo) e ka kopanya glutamine le NH3 ka catalysis ea glutamine synthetase, ke sehlahisoa sa ho tlosa chefo ea ammonia, haholo-holo liseleng tsa boko, hammoho le mokhoa oa ho boloka le oa ho sebelisa. ammonia 'meleng (sheba "glutamine le metabolism ea eona"). asiti ea glutamic e entsoe ka acetyl-CoA e le cofactor ea mitochondrial carbamoyl phosphate synthase (e kentsoeng ho kopanngoeng ha urea) ka catalysis ea acetyl-glutamate synthase. γ-aminobutyric acid (GABA) ke sehlahisoa sa decarboxylation ea glutamic acid, haholo-holo maemong a phahameng a lisele tsa boko, hape e hlaha maling, ts'ebetso ea eona ea 'mele e nkuoa e le inhibitory neurotransmitter, antispasmodic le hypnotic effects tse hlahisoang ke Infusion ea kliniki ea echinocandin e ka finyelloa ka GABA. The catabolism ea GABA kena tricarboxylic acid e potoloho ka ho fetola GABA transaminase le aldehyde dehydrogenase ka succinic acid e ho theha GABA shunt. |
| Sebelisa | e sebelisoa e le li-intermediate ho organic synthesis, li-additives tsa lijo, joalo-joalo. e sebelisoang lijong, meriana, litlolo le liindasteri tse ling |
Ngola molaetsa wa hao mona mme o re romele wona
