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Fmoc-O-tert-butyl-L-tyrosine(CAS# 71989-38-3) Setšoantšo se Featured
  • Fmoc-O-tert-butyl-L-tyrosine (CAS# 71989-38-3) 1

Fmoc-O-tert-butyl-L-tyrosine (CAS# 71989-38-3)

Thepa ea Lik'hemik'hale:

Foromo ea limolek'hule C28H29NO5
'Misa oa Molar 459.53
Botenya 1.218±0.06 g/cm3(E boletsoeng esale pele)
Melting Point ~150°C (Dec.)
Boling Point 658.2±55.0 °C(E boletsoeng esale pele)
Phetoho e khethehileng(α) -28 º (c=1, DMF)
Flash point 351.9°C
Solubility Chloroform (Hanyenyane), DMF (Hanyenyane), Methanol (Hanyenyane)
Khatello ea Mouoane 3.2E-18mmHg ho 25°C
Ponahalo Khalase e tšoeu
Mmala Bosoeu
BRN 4216652
pKa 2.97±0.10(E boletsoeng esale pele)
Boemo ba polokelo Boloka ka tlase ho +30°C.
Refractive Index -30 ° (C=1, DMF)
MDL MFCD00037129
Thepa ea 'Mele le ea Lik'hemik'hale Phofo e tšoeu ea kristale; Ha e kenelle metsing le petroleum ether, e qhibilihang ka har'a ethyl acetate, methanol le DMF;mp ke 150-151 ℃; Potoloho e khethehileng ea optical [α]20D 10 5.2 °(0.5-2.0 mg/ml, ethyl acetate),[α]20D-27.6 °(0.5-2.0 mg/ml,DMF),[α]20D-6 °(0.5- 2.0 mg/ml, methanol).

Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Matšoao a Kotsi Xi - Ea halefisang
Likhoutu tsa Kotsi 36/37/38 - Ho halefisa mahlo, tsamaiso ea ho hema le letlalo.
Tlhaloso ea Tšireletseho S26 - Ha u kopana le mahlo, hlatsoa hang-hang ka metsi a mangata 'me u batle keletso ea bongaka.
S24/25 - Qoba ho kopana le letlalo le mahlo.
WGK Jeremane 3
Khoutu ea HS 2924 29 70

 

Selelekela

Fluorene methoxycarbonyl-oxotert-butyl-tyrosine ke motsoako oa lik'hemik'hale o atisang ho khutsufatsoa joalo ka FMOC-Tyr(tBu)-OH. Se latelang ke selelekela sa sebopeho sa eona, ts'ebeliso, tokiso le tlhaiso-leseling ea polokeho:

 

Boleng:

- Ponahalo: Bosoeu kapa bosoeu bo tiileng.

- Solubility: E qhibiliha ka har'a lihlapolli tse ling tsa tlhaho, joalo ka dimethyl sulfoxide le dimethylformamide.

 

Sebelisa:

- Ho sireletsa lihlopha ka metsoako ea lik'hemik'hale: Lihlopha tsa FMOC li ka sebelisoa ho sireletsa lihlopha tsa amino ka metsoako ea phenolic ho li thibela ho itšoara. FMOC-Tyr(tBu) -OH e ka sebelisoa e le sesebelisoa sa ho qala bakeng sa ho lokisa liketane tsa peptide ka motsoako oa lik'hemik'hale.

 

Mokhoa:

Mokhoa oa ho lokisetsa FMOC-Tyr(tBu)-OH o ka finyelloa ka mehato e latelang:

- Fluorenyl chloride (FMOC-Cl) e sebetsanoa le tert-butyl (tBu-NH2) ho fana ka fluorenylmethoxycarbonyl-tert-butichsyl (FMOC-tBu-NH-).

- Ebe, arabela sephetho sa FMOC-tBu-NH- ka tyrosine (Tyr-OH) ho hlahisa FMOC-Tyr(tBu)-OH.

 

Lintlha tsa Tšireletseho:

- Tšebeliso ea FMOC-Tyr (tBu)-OH e itšetlehile ka ho lumellana le mekhoa ea tšireletso ea laboratori.

- Qoba ho ama letlalo le mahlo, 'me u roale liatlana tse sireletsang le likhalase ha u sebelisa.

- Sebelisa sebakeng se nang le moea o motle, hole le mollo le lintho tse tukang.

- Ha ea tlameha ho lokolloa tikolohong 'me e lokela ho tšoaroa le ho lahloa ho latela melao ea lehae.

 

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