Fmoc-L-2-Aminobutyric acid (CAS# 135112-27-5 )
Kotsi le Polokeho
| Tlhaloso ea Tšireletseho | S22 - U se ke ua hema lerole. S24/25 - Qoba ho kopana le letlalo le mahlo. |
| WGK Jeremane | 3 |
| Khoutu ea HS | 2924 29 70 |
| Sehlopha sa Likotsi | TS'OALANG |
Fmoc-L-2-Aminobutyric acid (CAS# 135112-27-5 ) Selelekela
L-2-(fluorenylmethoxycarbonylamino) butyric acid, e tsejoang hape e le Fmoc-glutamic acid (L-2-(9-fluorenylmethoxycarbonylamino) butyric acid), ke ntho ea tlhaho. E latelang ke tlhaloso ea tse ling tsa thepa ea eona, tšebeliso, mekhoa le tlhaiso-leseling ea polokeho:
Tlhaho:
-Ponahalo: phofo ea kristale e se nang mebala kapa e mosehla hanyane;
- Foromo ea molek'hule: C26H23NO4;
- Boima ba molek'hule: 413.47g / mol;
- ntlha ea ho qhibiliha: hoo e ka bang 166-168 ℃;
-Solubility: Fmoc-glutamic acid e qhibiliha ka har'a li-solvents tse kang dimethylformamide le hydrofluoric acid.
Sebelisa:
Fmoc-glutamic acid, e le motsoako oa sehlopha se sireletsang, hangata e sebelisoa ha ho etsoa peptide synthesis, haholo-holo ha ho etsoa tatellano e tsitsitseng ea peptide le motsoako oa Levenstein peptide (Levenshtein peptide). E ka sebelisoa e le motsoako oa maiketsetso oa li-amino acid, kapa oa sebelisoa ka mokhoa o tiileng oa motsoako, chromatography ea metsi a phahameng, joalo-joalo.
Mokhoa oa ho itokisa:
Ho lokisoa ha Fmoc-glutamic acid ka kakaretso ho kenyelletsa mehato e latelang:
1. Ka tsamaiso ea anhydrous, L-glutamic acid e sebetsanoa le Fmoc-OSu (fluorenylmethoxycarbonyl-chloro anhydride), 'me sodium chloride (NaCl) e sebelisetsoa ho khothalletsa karabelo ho hlahisa Fmoc-glutamic acid Fmoc-A letsoai.
2. Bakeng sa letsoai la Fmoc-glutamic acid, le qhibiliha ka har'a motsoako (joaloka dimethylformamide) 'me le tlas'a mokhoa o nepahetseng oa ho hloekisa (joaloka crystallization) ho fumana Fmoc-glutamic acid.
Lintlha tsa Tšireletseho:
Fmoc-glutamic acid hangata e tsitsitse ebile e na le chefo e tlase tlasa ts'ebetso e tloaelehileng. Empa joalo ka motsoako oa manyolo, o ntse o hloka ho ela hloko mehato e latelang ea polokeho:
- Qoba ho hema lerōle, ho kopana le letlalo le mahlo;
-Nakong ea ts'ebetso, roala liatlana tse sireletsang, likhalase le liaparo tse sireletsang tse finyellang litlhoko tsa tšireletso;
-Sebetsa sebakeng se nang le moea o motle oa moea ho qoba ho pepeseha ka ho toba nako e telele;
-Haeba litšila tse tsoang komporong ena li lokela ho lahloa, li lokela ho lahloa hantle ho latela melao ea lehae.
Tlhaho:
-Ponahalo: phofo ea kristale e se nang mebala kapa e mosehla hanyane;
- Foromo ea molek'hule: C26H23NO4;
- Boima ba molek'hule: 413.47g / mol;
- ntlha ea ho qhibiliha: hoo e ka bang 166-168 ℃;
-Solubility: Fmoc-glutamic acid e qhibiliha ka har'a li-solvents tse kang dimethylformamide le hydrofluoric acid.
Sebelisa:
Fmoc-glutamic acid, e le motsoako oa sehlopha se sireletsang, hangata e sebelisoa ha ho etsoa peptide synthesis, haholo-holo ha ho etsoa tatellano e tsitsitseng ea peptide le motsoako oa Levenstein peptide (Levenshtein peptide). E ka sebelisoa e le motsoako oa maiketsetso oa li-amino acid, kapa oa sebelisoa ka mokhoa o tiileng oa motsoako, chromatography ea metsi a phahameng, joalo-joalo.
Mokhoa oa ho itokisa:
Ho lokisoa ha Fmoc-glutamic acid ka kakaretso ho kenyelletsa mehato e latelang:
1. Ka tsamaiso ea anhydrous, L-glutamic acid e sebetsanoa le Fmoc-OSu (fluorenylmethoxycarbonyl-chloro anhydride), 'me sodium chloride (NaCl) e sebelisetsoa ho khothalletsa karabelo ho hlahisa Fmoc-glutamic acid Fmoc-A letsoai.
2. Bakeng sa letsoai la Fmoc-glutamic acid, le qhibiliha ka har'a motsoako (joaloka dimethylformamide) 'me le tlas'a mokhoa o nepahetseng oa ho hloekisa (joaloka crystallization) ho fumana Fmoc-glutamic acid.
Lintlha tsa Tšireletseho:
Fmoc-glutamic acid hangata e tsitsitse ebile e na le chefo e tlase tlasa ts'ebetso e tloaelehileng. Empa joalo ka motsoako oa manyolo, o ntse o hloka ho ela hloko mehato e latelang ea polokeho:
- Qoba ho hema lerōle, ho kopana le letlalo le mahlo;
-Nakong ea ts'ebetso, roala liatlana tse sireletsang, likhalase le liaparo tse sireletsang tse finyellang litlhoko tsa tšireletso;
-Sebetsa sebakeng se nang le moea o motle oa moea ho qoba ho pepeseha ka ho toba nako e telele;
-Haeba litšila tse tsoang komporong ena li lokela ho lahloa, li lokela ho lahloa hantle ho latela melao ea lehae.
Ngola molaetsa wa hao mona mme o re romele wona
