fmoc-O-tert-butyl-D-tyrosine (CAS# 118488-18-9)
Fmoc-O-tert-butyl-D-tyrosine ke amino acid e sirelelitsoeng hangata. E latelang ke tlhaloso ea sebopeho sa eona, tšebeliso, tlhahiso le tlhaiso-leseling ea polokeho:
Tlhaho:
Fmoc-O-tert-butyl-D-tyrosine ke 'mala o mosoeu oa kristale. Ke motsoako o nang le motsoako oa lik'hemik'hale C30H31NO7 le boima ba molek'hule ba 521.57g / mol. Motsoako o tsoa ho tyrosine moo sehlopha sa amino se nang le sehlopha se sireletsang Fmoc (9-fluorofluorenylformyl) le sehlopha sa carboxylic acid se esterified ka O-tert-butyl.
Sebelisa:
Fmoc-O-tert-butyl-D-tyrosine hangata e sebelisoa e le amino acid e sirelelitsoeng ka peptide synthesis. Ka ho hokela sehlopha sa tšireletso sa Fmoc sehlopheng sa amino, maikutlo a sa batleheng a ka thibeloa nakong ea ho kopanya. E sebelisoa haholo molemong oa ho kopanya likarolo tse tiileng mme e ka sebelisoa ho kopanya li-polypeptides le liprotheine.
Mokhoa oa ho itokisa:
Tokisetso ea Fmoc-O-tert-butyl-D-tyrosine hangata e etsoa ke motsoako oa lik'hemik'hale. Ntlha ea pele, tyrosine e itšoara ka Fmoc-Cl (9-fluorofluorenylcarbonyl chloride) ho hlahisa Fmoc-O-tyrosine. Cesium tert-butyl bromide e ntan'o eketsoa ho karabelo ho esterify sehlopha sa asiti ea carboxylic ho theha Fmoc-O-tert-butyl-D-tyrosine. Qetellong, sehlahisoa se hloekileng se fumanoa ka mehato ea crystallization, ho hlatsoa le ho omisa.
Lintlha tsa Tšireletseho:
Fmoc-O-tert-butyl-D-tyrosine ke motsoako o tsitsitseng tlas'a maemo a tloaelehileng 'me ha o na volatilization e hlakileng mocheso oa kamore. Nakong ea ts'ebeliso, hoa hlokahala ho latela mekhoa ea ts'ireletso ea laboratori, ho roala lisebelisoa tse nepahetseng tsa ts'ireletso, le ho qoba ho kopana le letlalo le mahlo. Ha e tšoaroa kapa e bolokoa, e lokela ho bolokoa sebakeng se omeletseng, se phodileng le hole le mollo le li-oxidizing agents. Ka nako e ts'oanang, ho kopana le li-oxidants tse matla le li-acid tse matla ho lokela ho qojoa ho thibela liketso tse kotsi. Batla thuso ea bongaka hang-hang haeba ho noa kapa ho pepesehela motsoako ka phoso.
