![Ethyl 1-(4-methoxyphenyl)-6-(4-aminophenyl)-7-oxo-4 5 6 7-tetrahydro-1H-pyrazolo[3 4-c]pyridine-3-carboxylate（CAS# 503615-07-4 ) Setšoantšo se Hlahisitsoeng](https://cdn.globalso.com/xinchem/Ethyl14methoxyphenyl64aminophenyl7oxo4567tetrahydro1Hpyrazolo34cpyridine3carboxylate.png)
Ethyl 1-(4-methoxyphenyl)-6-(4-aminophenyl)-7-oxo-4 5 6 7-tetrahydro-1H-pyrazolo[3 4-c]pyridine-3-carboxylate（CAS# 503615-07-4 )
Selelekela
Se latelang ke kenyelletso ea thepa, tšebeliso, mekhoa ea ho lokisetsa le tlhahisoleseding ea polokeho ea apixaban intermediate 3:
Boleng:
Apixaban intermediate 3 ke motsoako oa lintho tse phelang. E tiile 'me e qhibiliha ka har'a metsoako ea tlhaho e kang ether le ethyl acetate.
Lisebelisoa: Hangata e sebelisoa bakeng sa anesthesia ea ho buoa le ho phekola bohloko bo boholo.
Mokhoa:
Mokhoa oa ho lokisa apixaban intermediate 3 o ka etsoa ka mehato e latelang: p-nitrobenzoic acid e itšoara ka hypobutylthiourea ka ho ba teng ha acetic acid le thionyl chloride ho fumana N-(p-nitrophenyl) -N-(hypobutylthioyllurea) formic acid, 'me joale, e ile ea itšoara ka sodium hydroxide ka sodium oxide le methanol tharollo ho fumana apixaban mahareng 3.
Boitsebiso ba Tšireletseho: Mekhoa e tiileng ea ts'ebetso ea ts'ireletso e lokela ho lateloa ha u sebelisa le ho sebetsana le motsoako ona. Ho kopana ka ho toba kapa ho hema ho ka baka kotsi e tebileng bophelong ba motho. Lintlha tsa eona tse khethehileng tsa polokeho li lokela ho hlahlojoa le ho sebetsoa ho latela melao le litataiso tse amehang ho netefatsa ts'ebeliso le ts'ebetso e bolokehileng. Ha ho etsoa liteko tsa ho kopanya lik'hemik'hale, li lokela ho sebelisoa tlas'a maemo a loketseng a laboratori 'me ho lokela ho sebelisoa lisebelisoa tsa ts'ireletso tsa botho tse kang likhalase tsa lik'hemik'hale, liatlana tse sireletsang, le liaparo tse sireletsang.
