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Dodec-11-yn-1-ol (CAS# 18202-10-3)

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Dodec-11-yn-1-ol (CAS# 18202-10-3) Boitsebiso

tokisetso NaH (7.5g, 60% phallo ea oli, 326mmol) e ile ea eketsoa batch ka batch ho dodecyl -3-alkyne -1-alcohol (10.0g,54.95mmol; GF Smith) ka 0 ℃ tharollo ea ethylenediamine (40mL). Ka mor'a 1h, mocheso o nyolohela ho 70 ℃. Ka mor'a lihora tse ling tse 8, pholisa motsoako oa karabelo ho 0 ° C, ka hloko o khaotse ka metsi a batang a leqhoa (100mL), 'me u ntše ka ether (3 × 60mL). Motsoako oa ether o kopantsoeng o ne o hlatsuoa ka metsi (100mL). Ho hlatsoa metsi ho ile ha ntšoa ka morao ka ether (3 × 60mL). Li-extracts tse kopantsoeng tsa manyolo li ne li tsepamisitsoe ka har'a vacuum, 'me masalla a ile a kenngoa ka har'a kholomo ea chromatography ho sebelisoa 10% EtOAc/hexane ho fumana 11-dodecyne -1-alcohol (7.4g,74%) e silafalitsoeng ke 3-5% ea li-isomers tse ling tsa libaka. regioisomer). TLC:30% EtOAc/hexane, Rf ≈ 0.4;1H NMR(300MHz,CDCl3)δ3.66(t,2H,J = 7.3Hz), 2.14-2.21(m,2H),1.93(t,J = 1.9Hz) ,1H),1.20-1.63(m,16H).

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