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Cbz-L-Glutamic acid 1-benzyl ester (CAS# 3705-42-8) Setšoantšo se Hlahisitsoeng
  • Cbz-L-Glutamic acid 1-benzyl ester (CAS# 3705-42-8) 1

Cbz-L-Glutamic acid 1-benzyl ester (CAS# 3705-42-8)

Thepa ea Lik'hemik'hale:

Foromo ea limolek'hule C20H21NO6
'Misa oa Molar 371.38
Botenya 1.268±0.06 g/cm3(E boletsoeng esale pele)
Melting Point 92-93?C
Boling Point 594.3±50.0 °C(E boletsoeng esale pele)
Flash point 313.2°C
Ho qhibiliha ha Metsi E qhibiliha ka methanol, dimethyl sulfoxide. E qhibiliha hanyane ka metsing.
Solubility E qhibiliha ka Methanol
Khatello ea Mouoane 5.72E-15mmHg ho 25°C
Ponahalo Phofo ea kristale
Mmala Bosoeu
pKa 4.47±0.10 (E boletsoeng esale pele)
Boemo ba polokelo E tiisitsoe ka ho omme, Mocheso oa Kamore
Refractive Index 1.575
MDL MFCD00077013

Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

 

Selelekela

Z-Glu-OBzl(Z-Glu-OBzl) ke motsoako oa tlhaho o sebelisoang hangata e le sehlopha se sireletsang li-amino acid. E latelang ke tlhaloso ea thepa, tšebeliso, tokiso le tlhaiso-leseling ea polokeho ea komporo:

 

Tlhaho:

- Foromo ea molek'hule: C17H17NO4

- Boima ba molek'hule: 303.32g / mol

-Ponahalo: phofo e tšoeu ea kristale

- Sebaka se qhibilihang: 84-85°C

-Solubility: E qhibiliha ka har'a li-solvents tse kang dimethyl sulfoxide le dimethylformamide

- Sehlopha se sireletsang sa Cbz se ka tlosoa ke palladium hydride catalyst tlas'a maemo a acidic

 

Sebelisa:

- Z-Glu-OBzl ke sehlopha se sireletsang sa glutamic acid (Glu), se ka sebelisoang ho kopanngoa ha li-amino acid derivatives, polypeptides le protheine.

-E le sehlopha se sireletsang bakeng sa li-amino acid ka metsoako ea lintho tse entsoeng ka tlhaho, e ka sireletsa sehlopha sa amine sa glutamic acid, se thibela hore se se ke sa angoa ke liketso tse sa tsitsang, le ho thusa ho tlosoa ha ho hlokahala.

 

Mokhoa oa ho itokisa:

-Tokisetso ea Z-Glu-OBzl hangata e kenyelletsa ts'ebetso ea mehato e mengata mme e kenyelletsa letoto la lik'hemik'hale tsa lik'hemik'hale. E 'ngoe ea mekhoa e tloaelehileng ke ho qala ka ho sireletsa sehlopha sa carboxyl sa glutamic acid e le t-butoxycarbonyl ester (Boc) ebe o sireletsa sehlopha sa amino e le Cbz. Qetellong, sehlahisoa se lakatsehang Z-Glu-OBzl se thehoa ka karabelo e nang le benzyl chloroformate.

 

Lintlha tsa Tšireletseho:

- Z-Glu-OBzl e lokela ho tšoaroa e le metsoako e halefisang 'me e qobe ho kopana ka ho toba le letlalo le mahlo.

-Ha e sebelisoa ka laboratoring, mekhoa e nepahetseng ea tšireletso e tlameha ho lateloa, ho kenyeletsa ho roala likhalase tse sireletsang, liatlana le liaparo tsa laboratori.

-Ho hema kapa ho kenngoa ha motsoako ho lokela ho qojoa 'me mehato ea thibelo ea mollo le ho phatloha e lokela ho nkoa nakong ea polokelo.

-Motsoako o lokela ho behoa sebakeng se nang le moea o motle nakong ea ts'ebetso, 'me litšila li lokela ho lahloa hantle ho latela melao ea sebaka seo.

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