Carbobenzyloxy-beta-alanine (CAS# 2304-94-1)
| Matšoao a Kotsi | Xn - E Kotsi |
| Likhoutu tsa Kotsi | R22 – E kotsi ha e kwetswe R41 – Kotsi ya tshenyo e kgolo mahlong |
| Tlhaloso ea Tšireletseho | S26 - Ha u kopana le mahlo, hlatsoa hang-hang ka metsi a mangata 'me u batle keletso ea bongaka. S39 - Apara ts'ireletso ea mahlo / sefahleho. |
| WGK Jeremane | 2 |
| Khoutu ea HS | 29242990 |
| Sehlopha sa Likotsi | TS'OALANG |
Selelekela
Ke motsoako oa tlhaho oo sehlopha sa carboxyl (-COOH) se leng molek'hule ea alanine mohahong se nkeloe sebaka ke sehlopha sa benzyloxycarbonyl (-Cbz).
Thepa ea motsoako:
-Ponahalo: phofo e tšoeu ea kristale
- Foromo ea molek'hule: C12H13NO4
- Boima ba molek'hule: 235.24g / mol
- Sebaka se qhibilihang: 156-160 ° C
Lisebelisoa tse kholo ke tse latelang:
- Sebakeng sa motsoako oa manyolo, e ka sebelisoa e le setsi sa ho kopanya metsoako e meng e rarahaneng ea lintho tse phelang.
-E le sehlopha se sireletsang bakeng sa lithethefatsi tsa polypeptide tsa maiketsetso, e sebelisetsoa ho sireletsa masala a alanine.
- Bakeng sa lipatlisiso le ho lokisa limolek'hule tse ling tsa manyolo.
Mokhoa oa ho lokisa o ka aroloa ka mekhahlelo e latelang:
1. Boitšoaro ba benzyl chlorocarbamate ka sodium carbonate ho fumana benzyl N-CBZ-methylcarbamate (N-benzyloxycarbonylmethylaminoformate).
2. Etsa sehlahisoa se fumanoeng mohato o fetileng ka tharollo ea sodium hydroxide ho fumana N-CBZ-β-alanine.
Mabapi le litaba tsa polokeho:
-over ka kakaretso e nkoa e batla e bolokehile, empa mehato e nepahetseng ea ts'ebetso e ntse e hlokahala.
- Qoba ho kopana le letlalo, mahlo le molomo nakong ea tšebeliso.
-Apara liatlana tse sireletsang, likhalase le lijase tsa lab ha u etsa liteko.
- Qoba ho hema lerole le tsoang motsoakong.
-Motsoako o lokela ho bolokoa sebakeng se omeletseng, se pholileng, 'me se arohane le lintho tse tukang, li-oxidants le lintho tse ling.
Hoa lokela ho hlokomeloa hore tlhahisoleseding e fanoeng mona ke ea ho bua feela, 'me buka e nepahetseng ea liteko le leqephe la polokeho ea lik'hemik'hale li lokela ho botsoa pele u sebelisa motsoako, le ho latela melao ea ts'ireletso ea laboratori bakeng sa ts'ebetso.
