Boc-N-beta-Trityl-L-asparagine (CAS# 132388-68-2)

Tlhaloso ea Tšireletseho	S22 - U se ke ua hema lerole. S24/25 - Qoba ho kopana le letlalo le mahlo.
WGK Jeremane	3
Khoutu ea HS	2924 29 70
Sehlopha sa Likotsi	TS'OALANG

NAA-tert-butoxycarbonyl N Γ-trityl aspartamide ke motsoako oa tlhaho, oo hangata o bitsoang ka khutsufatso ea Boc-Phe-OtBu. E na le foromo ea C30H37NO4 'me e tiile e tšoeu.Nature:
Boc-Phe-OtBu e na le hydrophobic 'me ha e khone ho qhibiliha ka metsing, empa e qhibiliha habonolo ka har'a metsoako ea tlhaho e kang methanol, ethanol le dichloromethane. E batla e tsitsitse ho khanya le mocheso.

Sebelisa:
Boc-Phe-OtBu li sebelisoa haholo-holo bakeng sa ho sireletsa lihlopha le li-intermediate tsa karabelo ho organic synthesis. Ka har'a motsoako, e ka sebelisoa ho sireletsa li-amino acid tse nkhang hamonate, ka har'a motsoako oa polypeptides le liprotheine, ho sireletsa lihlopha tse sebetsang ho thibela ho hlaha ha karabelo ea lehlakore. Ho phaella moo, e ka boela ea sebelisoa ho lokisetsa metsoako e meng, e kang lithethefatsi, dae le lisebelisoa tsa manyolo.

Mokhoa oa ho itokisa:
Tokisetso ea Boc-Phe-OtBu e finyelloa haholo ke karabelo ea lik'hemik'hale. Mokgwa o mong o tlwaelehileng ke ho arabela p-benzoic acid ka t-butyl hydroxyformate ho hlahisa p-tert-butoxycarbonyl benzoate. E ntan'o itšoara ka triphenylamine ho fana ka sehlahisoa sa ho qetela sa Boc-Phe-OtBu.

Lintlha tsa Tšireletseho:
Boc-Phe-OtBu e batla e bolokehile tlasa ts'ebeliso e tloaelehileng. Leha ho le joalo, joaloka k’hemik’hale, e ntse e hloka ho bolokoa le ho sebetsoa ka nepo. Qoba ho kopana le li-oxidants tse matla, thibela ho hema lerōle le ho qoba ho ama letlalo. Nakong eo u e sebelisang, apara lisebelisoa tse loketseng tsa ho itšireletsa, tse kang liatlana le likhalase tse sireletsang. Ha ho ka etsahala hore motho a kopane kapa a jeoe ka phoso, batla keletso ea bongaka hang-hang 'me u fane ka boitsebiso ho ngaka mabapi le k'hemik'hale. Melao le melaoana ea polokeho ea lehae e lokela ho lateloa ha ho sebetsoa le ho lahla litšila.