BOC-D-2-Amino butyric acid (CAS# 45121-22-0)
| Sehlopha sa Likotsi | TS'OALANG |
Selelekela
Boc-D-Abu-OH(Boc-D-Abu-OH) ke motsoako oa tlhaho o nang le thepa e latelang:
1. ponahalo le thepa: boemo bo tloaelehileng ba 'mele ke kristale e tšoeu kapa phofo ea kristale.
2 thepa ea lik'hemik'hale: ke mofuta oa metsoako ea amide, e na le ho qhibiliha hantle, ka har'a li-solvents (tse kang dimethyl sulfoxide, dichloromethane, acetone, joalo-joalo) ka solubility e phahameng.
3. Botsitso: e batlang e tsitsitse tlas'a maemo a tloaelehileng, empa ho kopana le li-oxidants tse matla le maemo a phahameng a mocheso o lokela ho qojoa.
Likopo tsa Boc-D-Abu-OH li tsepamisitsoe haholo lefapheng la organic synthesis, e sebelisoang hangata ho chemistry ea meriana le lipatlisiso tsa biochemistry, lits'ebetso tse ikhethileng li kenyelletsa:
1. peptide synthesis: e le sehlopha se sireletsang, e ka ba ts'ebetsong ea peptide synthesis ho sireletsa sehlopha sa amine, ho se thibela ho itšoara ka tsela e sa khetheheng.
2. motsoako oa lithethefatsi: e ka sebelisoa e le setsi sa ho lokisa limolek'hule tsa lithethefatsi tse ka 'nang tsa e-ba teng le metsoako ea mokhethoa oa lithethefatsi.
3. Lithuto tsa ts'ebetso ea likokoana-hloko: Li-derivatives tsa Boc-D-Abu-OH li ka sebelisoa ho lekola tšebetso ea likokoana-hloko le thepa ea pharmacokinetic ea metsoako e itseng.
Mokhoa oa ho lokisa oa Boc-D-Abu-OH hangata o finyelloa ka mehato e latelang:
1. Sebelisa li-reagents tse loketseng ho fetola methyl propionate ka dimethyl sulfoxide ho N-BOC-alanine methyl ester.
2. N-BOC-alanine methyl ester e tsoela pele ho hydrolyzed tlas'a maemo a alkaline ho hlahisa Boc-D-Abu-OH.
Mabapi le tlhaiso-leseling ea polokeho ea Boc-D-Abu-OH, lintlha tse latelang li lokela ho hlokomeloa:
1. Kaha ke k'hemik'hale, e tlameha ho tšoaroa le ho bolokoa ka nepo, ho qoba ho kopana le letlalo le mahlo, le ho qoba mollo.
2. e sebelisoang e lokela ho latela mekhoa ea ts'ireletso ea laboratori.
3. Bakeng sa tlhahlobo ea polokeho ea lik'hemik'hale, ho lokela ho shejoe lipampiri tsa lintlha tsa polokeho le lingoliloeng ho netefatsa ts'ebeliso e nepahetseng le e bolokehileng.
