Boc-Asp-OtBu(CAS# 34582-32-6)

Selelekela

Boc-Asp-OtBu, eo hangata e tsejoang e le Boc-Asp-OtBu, ke motsoako oa manyolo. Se latelang ke selelekela ho tse ling tsa thepa ea eona, ts'ebeliso, tlhahiso le tlhaiso-leseling ea polokeho:

Tlhaho:

-Ponahalo: Lintho tse se nang 'mala tsa kristale kapa phofo.

- Foromo ea molek'hule: C≡H≡NO-7.

- Boima ba molek'hule: 393.47g / mol.

- Sebaka sa ho qhibiliha: hoo e ka bang 68-70°C.

-Solubility: E qhibiliha ka har'a li-solvents tse ling, tse kang dimethylformamide (DMF) le dichloromethane (DCM).

Sebelisa:

- Boc-Asp-OtBu ke sehlopha se atisang ho sebelisoa ho sireletsa, se atisang ho sebelisoa ha ho etsoa li-peptide le metsoako ea protheine. E ka sireletsa lihlopha tsa carboxyl le amino tsa glutamic acid (Asp) le ho thibela ts'ebetso ea kotsi le ho senyeha.

- Boc-Asp-OtBu e ka boela ea sebelisoa e le li-intermediate tsa karabelo ho organic synthesis, joalo ka peptide synthesis le synthesis ea lithethefatsi.

Mokhoa oa ho itokisa:

-Ka tloaelo, Boc-Asp-OtBu e lokiselitsoe ka ho sebetsana le amino acid e tšoanang (L-glutamic acid) le sehlopha sa tšireletso sa tert-butyl (Boc) le sehlopha sa tšireletso sa tert-butoxycarbonyl (OtBu). Boitšoaro bo etsoa tlas'a maemo a loketseng, mohlala ka ho kenyelletsa activator e kang 1-(trimethylsilyl) -1H-pyrazol-3-one (TBTU) kapa N,N'-disopropylmethylamide (DIPCDI) ka har'a motsoako oa tlhaho.

Lintlha tsa Tšireletseho:

- Boc-Asp-OtBu e nang le chefo e tlase.

-Hobane ke motsoako oa lintho tse phelang, qoba ho hema lerōle kapa ho kopana le letlalo le mahlo.

-Ha o sebetsa, o hloka ho latela mehato e nepahetseng ea ts'ireletso ea laboratori, joalo ka ho roala liatlana tse sireletsang le ts'ireletso ea mahlo.

-Ha e bolokoa, e lokela ho bolokoa sebakeng se phodileng, se omileng, le hole le mollo le li-oxidizing agents.

Litaba tse ka holimo ke tsa litšupiso feela, ka kopo latela lintlha tse nepahetseng tsa ts'ebetso ea liteko tsa lik'hemik'hale ha u sebelisa le ho sebetsana le Boc-Asp-OtBu.