ALPHA-ISO-METHYLIONONE(CAS#127-51-5)
| Matšoao a Kotsi | Xi - Ea halefisang |
| Likhoutu tsa Kotsi | 43 - E ka baka ts'oaetso ka ho kopana le letlalo |
| Tlhaloso ea Tšireletseho | S24/25 - Qoba ho kopana le letlalo le mahlo. S36/37 - Apara liaparo tse loketseng tsa tšireletso le liatlana. |
| Li-ID tsa UN | UN1230 - sehlopha sa 3 - PG 2 - Methanol, tharollo |
| WGK Jeremane | 2 |
| Chefo | GRAS (FEMA). |
Selelekela
tsebisa
Motsoako oa methyl le ethyl isomethyl violet ketone le methyl le ethyl ortho methyl violet ketone.
tlhaho
Alpha isomethylprednisolone ke motsoako oa lintho tse phelang. Ke kristale e pherese e tiileng. Mochesong oa kamore, e na le monko o monate o ikhethang.
Alpha isomethylprednisolone ke ketone e nkhang hamonate. E fumanoa ho tsoa ho methylation reaction ea violet alcohol mme e bitsoa isomethyl violet ketone. Sebopeho sa eona sa limolek'hule se na le reng e nkhang hamonate le sehlopha sa ketone.
Ka mocheso oa kamore, e tiile, empa e ka qhibiliha ka ho futhumatsa. Ha e qhibilihe ka metsing, empa e ka qhibiliha ka har'a metsoako e meng ea tlhaho e kang ethanol le dichloromethane. E na le kutloelo-bohloko ho khanya 'me e ka ba le maikutlo a photolysis tlas'a mahlaseli a mahlaseli a ultraviolet.
Mabapi le thepa ea lik'hemik'hale, α - isomethylprednisolone ke motsoako o sebetsang. E ka ba le karabelo e kang oxidation, phokotso, tlatsetso, le ho nkela sebaka. E sebetsana le li-reagents tse ling tsa electrophilic ho etsa lihlahisoa tsa tlatsetso. E ka ba protonated ka boteng ba acid e matla. E ka boela ea fetoloa ho ketone acid ka karabelo ea oxidation.
Mokhoa oa tlhahiso
Mokhoa o latelang ke o tloaelehileng oa ho hlahisa alpha isomethylprednisolone:
Tokisetso ea thepa ea pele: Lokisetsa lisebelisoa tsa pele, ho kenyelletsa Isobutyl ketone le Cyclohexanone. Lik'hemik'hale tsena tse peli ke li-precursor tsa bohlokoa bakeng sa motsoako oa α - isomethylprednisolone.
Boemo ba boemo ba ho itšoara: React isodecanone le cyclohexanol tlas'a maemo a loketseng. Boemo bo tloaelehileng ba ho itšoara ke ho tsamaisa karabelo tlas'a maemo a acidic, 'me li-catalysts tse tloaelehileng tsa acid li kenyelletsa sulfuric acid (H2SO4) le phosphoric acid (H3PO4).
Mehato ea ho itšoara: Kopanya palo e itseng ea isodecanone le cyclohexanol, 'me u kenye motsoako oa asiti. Ka mor'a moo, karabelo e etsoa ka mocheso o loketseng, ka mocheso o tloaelehileng o sebelisoang oa likhato tse 50-70 tsa Celsius. Nako ea ho arabela hangata ke lihora tse 'maloa ho isa ho lihora tse mashome.
Karohano le tlhoekiso: Ka mor'a hore karabelo e phethoe, sehlahisoa se hloekisoa ho tloha motsoako oa karabelo ka distillation kapa mekhoa e meng ea karohano.
Crystallization le ho omisa: Crystallize le ho omisa sehlahisoa se hloekisitsoeng ho fumana sehlahisoa sa ho qetela sa alpha isomethylprednisolone.
