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5-Fluorouracil (CAS# 51-21-8) Setšoantšo se Hlahisitsoeng
  • 5-Fluorouracil(CAS# 51-21-8) 1

5-Fluorouracil (CAS# 51-21-8)

Thepa ea Lik'hemik'hale:

Foromo ea limolek'hule C4H3FN2O2
'Misa oa Molar 130.08
Botenya 1.4593 (khakanyo)
Melting Point 282-286 °C (Dec.) (hote.)
Boling Point 190-200°C/0.1mmHg
Ho qhibiliha ha Metsi 12.2 g/L 20 ºC
Solubility E qhibiliha hanyane ka har'a ethanol. E batla e sa qhibilihe ka chloroform mme e qhibiliha ka tharollo ea sodium hydroxide.
Ponahalo Phofo ea kristale e tšoeu kapa e tšoeu
Mmala tšoeu
Merck 14,4181
BRN 127172
pKa pKa 8.0±0.1 (H2O) (Ha e na bonnete);3.0±0.1(H2O) (Ha e Netefatse)
PH 4.3-5.3 (10g/l, H2O, 20℃)
Boemo ba polokelo 2-8°C
Botsitso E tsitsitseng. Bohloko bo bobebe. E tukang. Ha e lumellane le lisebelisoa tse matla tsa oxidizing, metheo e matla.
E hloahloa Ha A na Moeeng
Refractive Index 1.542
MDL MFCD00006018
Thepa ea 'Mele le ea Lik'hemik'hale melting point 282-286°C (dec.)(lit.)maemo a polokelo Boloka ho 0-5
solubility H2O: 10 mg/mL, e hlakile

etsa phofo

mmala o mosoeu

ho qhibiliha ha metsi 12.2g/L 20 oC
Moea o Sensitive
merck 14,4181
BRN 127172
Sebelisa Bakeng sa mofetše oa tsamaiso ea tšilo ea lijo, mofets'e oa hlooho le molala, mofets'e oa basali, mofets'e oa matšoafo, mofets'e oa sebete, mofets'e oa senya le kalafo ea mofets'e oa letlalo.

Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Likhoutu tsa Kotsi R22 – E kotsi ha e kwetswe
R20/21/22 – E kotsi ka ho hema, ho kopana le letlalo le ha e koetsoe.
R52 – E kotsi ho dibopuwa tsa metsing
R25 – E chefo ha e koetsoe
Tlhaloso ea Tšireletseho S36 - Apara liaparo tse loketseng tsa tšireletso.
S36/37 - Apara liaparo tse loketseng tsa tšireletso le liatlana.
S36/37/39 - Apara liaparo tse loketseng tsa tšireletso, liatlana le tšireletso ea mahlo / sefahleho.
S22 - U se ke ua hema lerole.
S45 – Ha ho ka etsahala kotsi kapa ha o ikutlwa o sa phele hantle, batla keletso ya bongaka hanghang (bontsha leibole neng kapa neng ha ho kgoneha.)
S26 - Ha u kopana le mahlo, hlatsoa hang-hang ka metsi a mangata 'me u batle keletso ea bongaka.
Li-ID tsa UN UN 2811 6.1/PG 3
WGK Jeremane 3
RTECS YR0350000
LIKHOUTU FLUKA BRAND F 10-23
TSCA T
Khoutu ea HS 29335995
Tsebiso ea Kotsi E halefisang/ E na le Chefo e Haholo
Sehlopha sa Likotsi 6.1
Sehlopha sa ho paka III
Chefo LD50 ka molomo ho Mmutla: 230 mg/kg

 

Selelekela

Sehlahisoa sena se qala ho fetoloa 5-fluoro-2-deoxyuracil nucleotides 'meleng, e thibelang thymine nucleotide synthase le ho thibela phetoho ea deoxyuracil nucleotides ho deoxythymine nucleotides, kahoo e thibela DNA biosynthesis. Ho phaella moo, ka ho thibela ho kenngoa ha uracil le rotic acid ho RNA, phello ea ho thibela motsoako oa RNA e finyelloa. Sehlahisoa sena ke sethethefatsi se ikhethileng sa li-cell cycle, haholo-holo se thibelang S phase cell.

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