5-Fluorocytosine (CAS# 2022-85-7)
Kotsi le Polokeho
| Likhoutu tsa Kotsi | R40 - Bopaki bo fokolang ba phello ea kankere R36/37/38 – Ho tena mahlo, tsamaiso ya ho hema le letlalo. R63 – Kotsi e ka bang teng ya kotsi ho ngwana ya esong ho hlahe |
| Tlhaloso ea Tšireletseho | S22 - U se ke ua hema lerole. S24/25 - Qoba ho kopana le letlalo le mahlo. S45 – Ha ho ka etsahala kotsi kapa ha o ikutlwa o sa phele hantle, batla keletso ya bongaka hanghang (bontsha leibole neng kapa neng ha ho kgoneha.) S36/37 - Apara liaparo tse loketseng tsa tšireletso le liatlana. S36/37/39 - Apara liaparo tse loketseng tsa tšireletso, liatlana le tšireletso ea mahlo / sefahleho. S27 - Tlosa hang-hang liaparo tsohle tse silafetseng. S26 - Ha u kopana le mahlo, hlatsoa hang-hang ka metsi a mangata 'me u batle keletso ea bongaka. |
| WGK Jeremane | 2 |
| RTECS | HA6040000 |
| LIKHOUTU FLUKA BRAND F | 10-23 |
| Khoutu ea HS | 29335990 |
| Tsebiso ea Kotsi | E na le Chefo / Khanya e Kutloha |
| Sehlopha sa Likotsi | KHALEHANG, LESENYA |
| Chefo | LD50 ka litoeba (mg/kg):>2000 ka molomo le sc; 1190 ip; 500 iv (Grunberg, 1963) |
5-Fluorocytosine (CAS# 2022-85-7) Selelekela
boleng
Sehlahisoa sena ke phofo e tšoeu ea kristale e tšoeu kapa e tšoeu, e sa nkheng kapa e nkhang hanyenyane. E qhibiliha hanyane ka metsing, ho qhibiliha ha 1.2% ho 20 °C metsing, ho qhibiliha hanyenyane ka ethanol; E batla e sa qhibilihe ka har'a chloroform le ether; E qhibiliha ka hydrochloric acid e hlapollang kapa e hlapolla sodium hydroxide solution. E tsitsitse mocheso oa kamore, e fokotsa likristale ha ho bata, 'me karolo e nyenyane e fetoloa 5-fluorouracil ha e futhumala.
Sehlahisoa sena ke sethethefatsi sa antifungal se entsoeng ka 1957 mme se sebelisoa litsing tsa bongaka ka 1969, se nang le phello e hlakileng ea antibacterial ho Candida, cryptococcus, li-fungus tsa mebala le Aspergillus, 'me ha ho na phello e thibelang li-fungus tse ling.
Tšusumetso ea eona ea ho thibela li-fungus e bakoa ke ho kena ha eona liseleng tsa li-fungus tse nang le kutloelo-bohloko, moo tlas'a ketso ea nucleopyine deaminase, e tlosa lihlopha tsa amino ho theha antimetabolite-5-fluorouracil. Ea ho qetela e fetoloa 5-fluorouracil deoxynucleoside 'me e thibela thymine nucleoside synthetase, e thibela phetoho ea uracil deoxynucleoside ho thymine nucleoside,' me e ama DNA synthesis.
tshebediso
Li-antifungal. E sebelisoa haholo-holo bakeng sa candidiasis ea mucocutaneous, candidal endocarditis, ramatiki ea candidal, cryptococcal meningitis le chromomycosis.
Tšebeliso le litekanyetso Oral, 4 ~ 6g ka letsatsi, e arotsoe ka makhetlo a 4.
tshireletso
Lipalo tsa mali li lokela ho hlahlojoa khafetsa nakong ea tsamaiso. Bakuli ba nang le bothata ba sebete le liphio le mafu a mali le bakhachane ba lokela ho sebelisa ka hloko; Contraindicated ho bakuli ba matla renal insufficiency.
Ho boloka moriti, ho boloka moea.
