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5-Bromo-3-nitro-2-pyridinol (CAS# 15862-34-7) Setšoantšo se Hlahisitsoeng
  • 5-Bromo-3-nitro-2-pyridinol (CAS# 15862-34-7) 1

5-Bromo-3-nitro-2-pyridinol (CAS# 15862-34-7)

Thepa ea Lik'hemik'hale:

Foromo ea limolek'hule C5H3BrN2O3
'Misa oa Molar 218.99
Botenya 1.98±0.1 g/cm3(E boletsoeng esale pele)
Melting Point 246-250 °C
Boling Point 296.7±40.0 °C(E boletsoeng esale pele)
Flash point 133.2°C
Solubility DMSO, Methanol
Khatello ea Mouoane 0.00141mmHg ho 25°C
Ponahalo Tiileng
Mmala Bosehla
BRN 383853
pKa 6.31±0.10(E boletsoeng esale pele)
Boemo ba polokelo Boemo bo sa tsitsang, Mocheso oa Kamore
Refractive Index 1.647
MDL MFCD00023473

Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Kotsi le Polokeho

Likhoutu tsa Kotsi R22 – E kotsi ha e kwetswe
R37/38 – E tenang tsamaiso ya ho hema le letlalo.
R41 – Kotsi ya tshenyo e kgolo mahlong
R36/37/38 – Ho tena mahlo, tsamaiso ya ho hema le letlalo.
R20 – E kotsi ka ho hema
Tlhaloso ea Tšireletseho S26 - Ha u kopana le mahlo, hlatsoa hang-hang ka metsi a mangata 'me u batle keletso ea bongaka.
S36/37/39 - Apara liaparo tse loketseng tsa tšireletso, liatlana le tšireletso ea mahlo / sefahleho.
S36 - Apara liaparo tse loketseng tsa tšireletso.
Li-ID tsa UN 2811
WGK Jeremane 3
Khoutu ea HS 29337900
Tsebiso ea Kotsi E kotsi
Sehlopha sa Likotsi TS'OALANG

Boitsebiso ba Litšupiso

Sebelisa 5-bromo-2-hydroxy-3-nitropyridine ke organic intermediate e ka sebelisoang ho lokisa metsoako 3-amino-1-(2-oxo-2-(3 '-(trifluoromethyl)-[1,1'-biphenyl ]-4-yl) ethyl) -5-(pyrrole
alkyl-1-yl-sulfonyl) pyridin-2 (1H)-one, motsoako ona ke motsoako o thibelang DOCK1.
mokhoa oa ho kopanya asiti ea nitric (60-61%,3.5mL) e ile ea eketsoa ka tharollo (10mL) ea 5-bromopyridine -2 (1H) -e le 'ngoe (1.75g,10.1mmol) ka sulfuric acid ka 0 ℃. Motsoako o lumelloa ho futhumala mocheso oa kamore ebe o hlohlelletsa lihora tse 3. Motsoako oa karabelo o tšeloa ka metsing a leqhoa 'me sephetho se hlahisoang se bokelloa ka ho sefa. Sehlahisoa se hlahisoang se ile sa hlatsuoa ka metsi 'me sa omisoa ka vacuum, ho fana ka 5-bromo-2-hydroxy-3-nitropyridine (960mg,43% chai) e le tiileng e tšoeu. 1H
NMR(500MHz,CDCl3)δ:8.57(s,1H),8.26(s,1H).
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