5-Bromo-2-fluoro-4-methyl-pyridine (CAS# 864830-16-0)
| Likhoutu tsa Kotsi | R22 – E kotsi ha e kwetswe R37/38 – E tenang tsamaiso ya ho hema le letlalo. R41 – Kotsi ya tshenyo e kgolo mahlong |
| Tlhaloso ea Tšireletseho | S26 - Ha u kopana le mahlo, hlatsoa hang-hang ka metsi a mangata 'me u batle keletso ea bongaka. S39 - Apara ts'ireletso ea mahlo / sefahleho. |
| Sehlopha sa Likotsi | TS'OALANG |
Selelekela
Ke motsoako oa manyolo o nang le foromo ea molek'hule C≡H∞BrFN, e nang le athomo ea fluorine, sehlopha sa methyl le athomo ea bromine e nketsoeng sebaka sa lesale la pyridine.
Tlhaho:
ke ntho e tiileng, e chefo ebile e teneha. E qhibiliha ka har'a metsoako ea tlhaho e kang ethanol le dimethylformamide ka mocheso oa kamore, 'me e ka kopanya hydrogen le tse ling tse amohelang hydrogen bond (mohlala, alcohols).
Sebelisa:
Hangata e sebelisoa e le ntho ea ho qala kapa e bohareng ba karabelo ea organic synthesis. E ka sebelisoa ho lokisetsa meriana, chefo e bolaeang likokoanyana le metsoako e meng ea manyolo. Mefuta e mengata ea ts'ebeliso ea eona e kenyelletsa lipatlisiso tsa meriana, motsoako oa lik'hemik'hale le saense ea thepa.
Mokhoa oa ho itokisa:
Mokhoa oa ho itokisa oa fluorination o ka finyelloa ka benzyl bromination le fluorination. Ntlha ea pele, motsoako oa benzyl (4-methylpyridine) o itšoara ka benzylidene bromide ho hlahisa motsoako oa bromobenzyl (2-bromo-4-methylpyridine). Ka mor'a moo, motsoako ona o sebetsa ka hydrofluoric acid ho hlahisa sehlahisoa se lumellanang sa fluorinated (phosphonium).
Lintlha tsa Tšireletseho:
e chefo, e lokela ho nka mehato e loketseng ea ho itšireletsa. Qoba ho kopana le letlalo, mahlo le phefumoloho nakong ea ts'ebetso. E lokela ho sebelisoa sebakeng se nang le moea o motle, 'me u roale likhalase tse sireletsang, liatlana le limaske. Ipolokele hole le li-oxidizing agents, 'me u qobe ho kopana le lik'hemik'hale tse ling. Haeba o pepesitsoe kapa o hema, batla keletso ea bongaka hang-hang.
