4-Bromo-3-fluorobenzoic acid (CAS# 153556-42-4)
Boitsebiso ba Litšupiso
| Lisebelisoa | 4-bromo-3-fluorobenzoic acid ke ntho ea bohlokoa ea lik'hemik'hale tse tala tse ka sebelisoang ho lokisetsa mefuta e sa tšoaneng ea lithethefatsi (e kang benzamit e khahlanong le kankere). |
| Mokhoa oa ho kopanya | 4-bromo-3-fluorobenzoic acid e ka fumanoa ka oxidation ea 4-bromo-3-fluorotoluene ka potassium permanganate. (1) oxidation: 100kg ea kg4-bromo -3-fluorotoluene, 120kg ea metsi le 0.1kg ea mafura a joala a polyether sodium sulfate (AES) li eketsoa ka tatellano ho kettle e entsoeng ka khalase ea K-400L (e entsoeng ke lesela la lik'hemik'hale la Jiangsu equipment co., ltd.) ka ho hlohlelletsa le ho futhumatsa le condensation reflux sesebelisoa, ka nako eo 167kg ea potassium permanganate e kenngoa butle-butle tlas'a boemo bo susumetsang, e bolokiloe boemong bo belang, 'me e itšoara ka lihora tse 9, emisa karabelo ka mor'a hore tharollo ea reflux e se e se na lifaha tsa oli; (2) Filtration: sefa tharollo ea karabelo e fumanoang mohatong oa (1) ha e ntse e chesa ho fumana filtrate e nang le sehlahisoa sa sepheo sa 4-bromo -3-fluorobenzoic acid; (3) Tlosa potassium permanganate: Bakeng sa ho tlosa potassium permanganate e setseng ka har'a filtrate, 0.1kg ea sodium sulfite e tlameha ho eketsoa ho filtrate e fumanoeng mohatong oa (2), palo ea tlatsetso ea sodium sulfite e ipapisitse le mokelikeli o pepeneneng. mmala o pherese wa tharollo. (4) acidification: boemong bo susumetsang, butle-butle eketsa ntho ho tharollo e fumanoang mohatong oa (3) ka motsoako oa 12mol / L concentrated hydrochloric acid. ha pH boleng ba tharollo ke 2.2, khaotsa ho eketsa concentrated hydrochloric acid le tsoela pele karabelo bakeng sa 30min. (5) crystallization: boemong bo tsosang takatso, tharollo e fumanoeng mohato (4) e pholile ho 2 ° C, 'me likristale tse entsoeng ka tharollo ke 4-bromo-3-fluorobenzoic acid. Nakong ea ts'ebetso, e tlameha ho tsosoa ka ho tsoelang pele, ho seng joalo 4-bromo-3-fluorobenzoic acid e tla theha sepakapaka se seholo, seo ho leng thata ho sebetsana le sona ka mekhoa e latelang; (6) Ho sefa le ho hlatsuoa: Mokelikeli o tsoakiloeng o nang le likristale tsa 4-bromo-3-fluorobenzoic acid tse fumanoeng mohatong oa (5) o tšeloa centrifuged ho fumana kuku e sefang eo e leng sehlahisoa sa 4-bromo-3-fluorobenzoic acid, sehlahisoa se tala. e hlatsuoa ka metsi a hloekileng le centrifuged (ho sebelisa centrifuge e nang le ts'ebetso ea ho hlatsoa) ho fumana e hloekisitsoeng. 4-bromo-3-fluorobenzoic acid; (7) Ho omisa: 4-bromo-3-fluorobenzoic acid e tiileng e lokiselitsoeng mohatong oa (6) e omisitsoe ho 75 ° C bakeng sa lihora tse 12 ho fumana 197 kg4-bromo-3-fluorobenzoic acid, eo litaba tsa eona li fetang 98. %. |
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