3-CHLORO-2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE (CAS# 76041-71-9)
| Likhoutu tsa Kotsi | R25 – E chefo ha e koetsoe R36/37/38 – Ho tena mahlo, tsamaiso ya ho hema le letlalo. |
| Tlhaloso ea Tšireletseho | S26 - Ha u kopana le mahlo, hlatsoa hang-hang ka metsi a mangata 'me u batle keletso ea bongaka. S36/37 - Apara liaparo tse loketseng tsa tšireletso le liatlana. S45 – Ha ho ka etsahala kotsi kapa ha o ikutlwa o sa phele hantle, batla keletso ya bongaka hanghang (bontsha leibole neng kapa neng ha ho kgoneha.) |
| WGK Jeremane | 3 |
| Khoutu ea HS | 29333990 |
| Sehlopha sa Likotsi | TS'OALANG |
Selelekela
3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine ke motsoako oa lintho tse phelang. Se latelang ke selelekela sa sebopeho sa eona, tšebeliso, mekhoa ea tlhahiso le tlhaiso-leseling ea polokeho:
1. Tlhaho:
- Ponahalo: 3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine ha e na 'mala ho isa mosehla o mosehla o tiileng.
- Sollubility: E batla e sa qhibilihe ka metsing, empa e qhibiliha ka har'a metsoako ea tlhaho e kang ether, methanol le methylene chloride.
- Lits'ebetso tsa lik'hemik'hale: Ke motsoako oa alkaline o etsang hore ho be le phello e fokolang khahlanong le acid. E ka boela ea sebelisoa e le reagent ea fluorinating ho hlahisa lihlopha tsa trifluoromethyl ka har'a metsoako e meng ea tlhaho.
2. Tšebeliso:
- 3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine e atisa ho sebelisoa ho organic synthesis reactions e le catalyst kapa reagent. Ka mohlala, e ka sebelisoa ho etsa li-bond tsa carbon-fluorine le liketso tsa amination.
- E ka boela ea sebelisoa e le ntho ea ho qala kapa ea lipakeng tsa motsoako oa chefo e bolaeang likokoanyana.
3. Mokhoa:
- Mokhoa o tloaelehileng oa ho itokisa ke ho arabela pyridine ka trifluoroformic acid le sulfuric acid ho hlahisa 3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine.
4. Litaba tsa Polokeho:
- 3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine e lokela ho qojoa nakong ea polokelo le ho sebelisoa ha e kopana le li-oxidants tse matla le lintho tse tukang ho qoba mollo kapa ho phatloha.
- E ka 'na ea e-ba le phello e khopisang letlalong, mahlo, le pampiri ea ho hema,' me lisebelisoa tse loketseng tsa tšireletso tse kang li-gloves, likhalase le lisebelisoa tsa ho itšireletsa li lokela ho apesoa ha li sebetsa.
- Ha o sebelisa kapa o sebetsana le motsoako, o lokela ho etsoa sebakeng se nang le moea o motle 'me u qobe ho hema kapa ho kenngoa ka phoso. Ka mor'a phekolo, sebaka se silafetseng se lokela ho hloekisoa hantle.
