2,4,5-Trifluorophenylacetic Acid (CAS# 209995-38-0)
Kopo
2,4, 5-trifluorophenylacetic acid ke mokelikeli o mosoeu o sebelisetsoang ho etsa sethethefatsi se secha sa sitagliptin bakeng sa kalafo ea lefu la tsoekere la mofuta oa II. sitagliptin ke inhibitor ea pele ea DPP-IV e sa tsoa thathamisoa ke Merck. E na le phello e ntle ea ho folisa, litlamorao tse nyane, polokeho e ntle le mamello kalafong ea lefu la tsoekere la mofuta oa II, 'me e na le menyetla e mengata ea mmaraka.
Tlhaloso
Ponahalo ea Crystallization
Mmala o Mosoeu ho isa ho o Mosoeu
pKa 3.78±0.10(E boletsoeng esale pele)
Maemo a Polokelo a Tiisitsoeng ka omileng, Mocheso oa Kamore
Refractive Index 1.488
Polokeho
Matshwao a Kotsi Xi - E tenang
E tenang
Likhoutu tsa Kotsi R37/38 - Ho halefisa tsamaiso ea ho hema le letlalo.
R41 - Kotsi ya tshenyo e kgolo mahlong
Tlhaloso ea Tšireletseho S26 - Ha u kopana le mahlo, hlatsoa hang-hang ka metsi a mangata 'me u batle keletso ea bongaka.
S39 - Apara ts'ireletso ea mahlo / sefahleho.
WGK Jeremane 3
HS Code 29163990
Kotsi Class TSOHLE
Ho paka & Polokelo
E pakiloeng ka meqomong ea 25kg/50kg. Boloka sebakeng se lefifi, se tiisitsoe moo ho omileng, Mocheso oa Kamore
Selelekela
E hlahisa 2,4,5-Trifluorophenylacetic Acid, e tiileng e tšoeu e sebelisoang haholo indastering ea meriana bakeng sa ho kopanya li-intermediate tsa sitagliptin bakeng sa phekolo ea lefu la tsoekere la mofuta oa II.
E le karolo ea bohlokoa tlhahisong ea sitagliptin, 2,4,5-Trifluorophenylacetic Acid e phethile karolo ea bohlokoa ntlafatsong ea moriana ona o sebetsang hantle haholo. Sitagliptin ke inhibitor ea morao-rao ea DPP-IV e sa tsoa thathamisoa ke Merck. E ithorisa ka litlamorao tse ntle tsa kalafo, litlamorao tse fokolang, polokeho le mamello, 'me e fetohile setlhare se sebelisoang kalafong ea lefu la tsoekere la mofuta oa II.
E 'ngoe ea melemo ea bohlokoa ea 2,4,5-Trifluorophenylacetic Acid ke hore e nolofalletsa tlhahiso ea sitagliptin ka theko e tlaase, e lumellang batho ba bangata ho fumana meriana ena e fetolang bophelo. Ho feta moo, e sebetsa haholo kalafong ea lefu la tsoekere mme e fana ka tšepo e ncha ho ba loanang le boemo bona.
Ponahalo ea 2,4,5-Trifluorophenylacetic Acid ke phofo e tšoeu ea kristale ho ea ho e tšoeu, e etsang hore ho be bonolo ho khetholla, ho tšoara le ho tsamaisa. E boetse e batla e tsitsitse tlas'a maemo a tloaelehileng, ho bolelang hore e ka bolokoa nako e telele ntle le ho senya.
2,4,5-Trifluorophenylacetic Acid e na le mefuta e mengata haholo 'me e ka sebelisoa ha ho etsoa metsoako e meng e rarahaneng ho feta sitagliptin intermediates. E na le lits'ebetso tse fapaneng tsa indasteri, ho kenyelletsa tlhahiso ea lik'hemik'hale tsa agrochemicals, li-resin le li-intermediates. E ka boela ea sebelisoa e le ntho e qalang bakeng sa ho qaptjoa ha mefuta e mengata ea limolek'hule tse nang le lisebelisoa tse fapaneng.
Khamphani ea rona, re motlotlo ka ho fana ka 2,4,5-Trifluorophenylacetic Acid ea boleng bo holimo ho bareki ba rona. Sehlahisoa sa rona se finyella litekanyetso tsa boleng bo phahameng ka ho fetisisa 'me se etsoa ho latela litataiso tse tiileng ho netefatsa ho tsitsa le ho hloeka.
Qetellong, 2,4,5-Trifluorophenylacetic Acid ke motsoako oa bohlokoa haholo o fetohileng karolo ea bohlokoa tlhahisong ea sitagliptin, moriana oa pele oa lefu la tsoekere la mofuta oa II. Ho ikamahanya le maemo le ho sebetsa ha eona ho etsa hore e be letlotlo la bohlokoa indastering ea meriana le ea lik'hemik'hale, 'me re motlotlo ho fana ka 2,4,5-Trifluorophenylacetic Acid ea boleng bo holimo ho bareki ba rona.
