2′-Deoxy-4′-C-ethynyl-2-fluoadenosine(CAS#865363-93-5)
Re hlahisa 2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine (CAS:865363-93-5), e leng analoge e matla ea nucleoside e reretsoeng ho fetola lefapha la baeloji ea limolek'hule le lipatlisiso tsa meriana. Motsoako ona oa boqapi o etselitsoe ho ntlafatsa kutloisiso ea litšebelisano tsa nucleic acid le lits'ebetso tsa cellular, e leng se etsang hore e be sesebelisoa sa bohlokoa ho bafuputsi le bo-ramahlale ka ho ts'oana.
2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine e khetholloa ke liphetoho tsa eona tse ikhethang tsa sebopeho, tse kenyelletsang li-substitutes tsa ethynyl le fluorine sebakeng sa 4 le 2, ka ho latellana. Liphetoho tsena ha li ntlafatse feela botsitso le bioavailability ea motsoako empa hape li matlafatsa bokhoni ba eona ba ho phunyeletsa lera la cellular, e leng ho lumellang hore ho be le phano e atlehang haholoanyane le ho amoheloa lits'ebetsong tse fapaneng tsa likokoana-hloko.
Analog ena ea nucleoside e bonts'itse menyetla e ts'episang lits'ebetsong tse fapaneng, ho kenyeletsoa lipatlisiso tsa antiviral le anticancer. Bokhoni ba eona ba ho etsisa li-nucleosides tsa tlhaho ha e ntse e bonts'a likarolo tse ikhethang tsa biochemical e etsa hore e be mokhethoa ea loketseng bakeng sa nts'etsopele ea lisebelisoa tse ncha tsa kalafo. Bafuputsi ba ka sebelisa 2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine ho ithuta RNA le DNA synthesis, ho etsa lipatlisiso tsa ho sebelisana ha enzyme, le ho hlahloba mekhoa ea tšebetso ea lithethefatsi tse seng li ntse li le teng.
Ntle le likopo tsa eona tsa lipatlisiso, motsoako ona o boetse o ikemiselitse ho phetha karolo ea bohlokoa ho nts'etsopele ea mekhoa ea phekolo ea moloko o latelang. Ka ho fana ka lintlha tse mabapi le boits'oaro le litšebelisano tsa nucleic acid, 2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine e ka thusa ho theha mekhoa ea phekolo e sebetsang haholoanyane le e lebisitsoeng bakeng sa maloetse a sa tšoaneng.
Ka kakaretso, 2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine (CAS:865363-93-5) ke analoge ea morao-rao ea nucleoside e fanang ka menyetla e ke keng ea bapisoa ea lipatlisiso le nts'etsopele ea baeloji ea limolek'hule le pharmacology. Amohela bokamoso ba tšibollo ea mahlale ka motsoako ona o ikhethang 'me u notlolle menyetla e mecha mesebetsing ea hau ea lipatlisiso.
