2-(chloromethyl) -5-(trifluoromethyl) -1 3 4-oxadiazole (CAS# 723286-98-4)

Thepa ea Lik'hemik'hale:

Foromo ea limolek'hule	C4H2ClF3N2O
'Misa oa Molar	186.52
Botenya	1.555±0.06 g/cm3(E boletsoeng esale pele)
Boling Point	55-60 °C(Tobetsa: 10 Torr)
Flash point	41.1°C
Solubility	Chloroform (e qhibilihang), Methanol (Hanyenyane)
Khatello ea Mouoane	6.44mmHg ho 25°C
Ponahalo	Oli
Mmala	Bosehla bo Bosehla ho isa Bosehla
pKa	-8.11±0.44(E boletsoeng esale pele)
Boemo ba polokelo	Boloka sebakeng se lefifi, se se nang moea, Boloka ka sehatsetsing, ka tlas'a -20°C
Refractive Index	1.406

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Selelekela

2-(chloromethyl) -5-(trifluoromethyl) -1,3,4-oxadiazole ke motsoako oa manyolo o nang le foromo C4H2ClF3N2O.

Tlhaho:

2-(chloromethyl) -5-(trifluoromethyl) -1,3,4-oxadiazole ke mokelikeli o mosehla o mosehla o se nang mebala kapa o tiileng oa crystalline. E na le botsitso bo phahameng ba mocheso le inertness ea lik'hemik'hale. Ha e qhibilihe ka metsing a mocheso oa kamore, 'me e qhibiliha ka har'a metsoako e meng ea tlhaho e kang ethanol le ether. Motsoako ona o ka khetholloa ka mekhoa e kang nuclear magnetic resonance le mass spectrometry.

Sebelisa:

2-(chloromethyl) -5-(trifluoromethyl) -1,3,4-oxadiazole e na le boleng bo itseng ba kopo lefapheng la k'hemistri. Hangata e sebelisoa e le karolo e bohareng ea organic synthesis bakeng sa motsoako oa metsoako e meng. Ho feta moo, e boetse e sebelisoa e le setsi sa lipatlisiso lefapheng la chefo e bolaeang likokoanyana le meriana.

Mokhoa oa ho itokisa:

2-(chloromethyl) -5-(trifluoromethyl) -1,3,4-oxadiazole e ka etsoa ka mekhoa e sa tšoaneng. E latelang ke mokhoa o tloaelehileng oa ho lokisa:

1. Eketsa catalyst (e kang triethylamine) ho anhydrous organic reaction solvent system.

2. Kenya tekanyo e itseng ea methyl 3-chloropropionate le methyl trifluoroformate tsamaisong ea solvent.

3. Karabelo e etsoa ka mocheso o loketseng tlas'a sepakapaka sa inert, 'me hangata hoa hlokahala ho futhumatsa motsoako oa karabelo.

4. Filtration kapa distillation ho fumana sehlahisoa, ka mor'a tlhoekiso e loketseng le ho omisa ho fumana sehlahisoa se hloekileng.

Lintlha tsa Tšireletseho:

2-(chloromethyl) -5-(trifluoromethyl) -1,3,4-oxadiazole hangata e bolokehile ha e sebelisoa le ho bolokoa ka nepo. Leha ho le joalo, joalo ka motsoako oa manyolo, o ka baka kotsi e itseng bophelong ba batho le tikolohong. Ts'ebetsong le ts'ebetsong, li lokela ho latela mekhoa e nepahetseng ea ts'ireletso, 'me li qobe ho kopana ka ho toba. Litaelo tse nepahetseng tsa tšireletso bakeng sa motsoako li lokela ho baloa ka hloko le ho lateloa. Haeba ho hlokahala, ts'ebetso e lokela ho etsoa tlas'a tataiso ea basebetsi ba litsebi.

E fetileng: Fmoc-Ls(Trt)-OH（CAS# 719892-61-2)

E 'ngoe: Fmoc-L-Serine (CAS# 73724-45-5)

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