2-Chloro-3-fluoro-6-picoline (CAS# 374633-32-6)
Selelekela
Ponahalo: Hangata ha e na 'mala ho ea ho mokelikeli o mosehla o khanyang, litšobotsi tsena tsa ponahalo li fana ka maikutlo a hore e ka ba le maikutlo a bobebe le mocheso,' me hoa hlokahala ho nka mehato ea ho qoba ho laola leseli le mocheso nakong ea polokelo le lipalangoang, joalo ka ho sebelisa libotlolo tsa khalase tse sootho le ho li boloka. ka setorong se phodileng ho thibela ho teba le ho senyeha ha mmala.
Solubility: Motsoako o na le ho qhibiliha hamonate ho li-solvents tse tloaelehileng, tse kang toluene le dichloromethane, ho latela molao-motheo oa ho qhibiliha ho tšoanang, 'me o na le kamano le metsoako ea tlhaho ka lebaka la karolo ea hydrophobic ea molek'hule; Leha ho le joalo, ho qhibiliha ha metsi ho tlaase, 'me maqhama a matla a hydrogen pakeng tsa limolek'hule tsa metsi a thata ho robeha ka katleho ke molek'hule, ho etsa hore ho be thata ho e hasanya.
Sebaka sa ho belisa le ho teteana: Lintlha tsa lintlha tsa ho belisa li amana haufi-ufi le ho feto-fetoha ha tsona 'me li ka fana ka lintlha tsa bohlokoa bakeng sa ts'ebetso e kang distillation le tlhoekiso, empa ka bomalimabe boleng bo khethehileng ba ntlha ea ho bela ha bo so ka bo senoloa hohle. Boima ba eona bo phahame hanyane ho feta ba metsi, 'me ho utloisisa ho teteana ho ka thusa ho hakanya ka nepo kamano ea phetoho ea bongata bo bongata lits'ebetsong tsa liteko kapa lits'ebetsong tsa indasteri tse joalo ka phetiso ea mokelikeli le metara e nepahetseng.
Lintho tsa lik'hemik'hale
Phetoho ea sebaka: Athomo ea chlorine le athomo ea fluorine ka molek'hule ke libaka tse ka bang teng tsa ts'ebetso. Ka ts'ebetsong ea nucleophilic substitution, li-nucleophile tse matla li ka hlasela libaka tseo liathomo tsa chlorine le fluorine li leng ho tsona, li nkela liathomo tse lumellanang le tsona, 'me li hlahise lihlahisoa tse ncha tsa pyridine. Ka mohlala, e kopantsoe le li-nucleophile tse nang le naetrojene le sebabole ho hlahisa letoto la metsoako ea heterocyclic e nang le naetrojene e nang le mekhoa e rarahaneng haholoanyane bakeng sa ho sibolloa ha lithethefatsi kapa motsoako oa lintho tse bonahalang.
Redox reaction: lesale la pyridine ka boeona le batla le tsitsitse, empa ha li-oxidants tse matla, tse kang potassium permanganate le hydrogen peroxide li kopantsoe le maemo a acidic, ho ka etsahala hore ho be le oxidation, e leng se fellang ka ho timetsoa kapa ho fetoloa ha sebopeho sa lesale la pyridine; Ka lehlakoreng le leng, ka mokhoa o loketseng oa ho fokotsa, joalo ka li-hydrides tsa tšepe, ho ka boleloa hore ho ka khoneha ho hydrogenation ea intramolecular unsaturated bonds.
Ea bone, mokhoa oa ho kopanya
Mokhoa o tloaelehileng oa ho kopanya ke ho qala ho tsoa ho li-derivatives tse bonolo tsa pyridine ebe butle-butle o haha mohaho o reriloeng ka halogenation le karabelo ea fluorination. Lintho tse qalang tsa metsoako ea pyridine li qala ka ho khetha methylated le lihlopha tsa methyl li hlahisoa ka nako e le 'ngoe; Ebe u sebelisa li-halogenation reaagents, tse kang chlorine le chlorine ea metsi, e nang le li-catalyst tse loketseng le maemo a itšoarang, ho finyella ho kenngoa ha liathomo tsa chlorine; Qetellong, li-reagents tse nang le fluorinated, tse kang Selectfluor, li ne li sebelisetsoa ho etsa fluorinate sebaka se lebisitsoeng ho fumana 2-chloro-3-fluoro-6-methylpyridine.
Lisebelisoa
Lithethefatsi synthesis intermediates: sebopeho sa eona se ikhethang se ratoa ke litsebi tsa lik'hemik'hale tsa meriana, 'me ke setsi sa boleng bo holimo bakeng sa nts'etsopele ea litlhare tse ncha tsa antibacterial, antiviral le antitumor. Thepa ea elektronike le sebopeho sa sebaka sa mehele ea pyridine le tse ling tsa tsona li ka tlama ka ho khetheha ho lebisa liprotheine ka vivo, 'me li lebeletsoe hore li fetohe metsoako e sebetsang ka katleho e babatsehang ka mor'a liphetoho tse ngata tse latelang.
Materials science: Sebakeng sa organic material synthesis, e ka sebelisoa ho etsa lisebelisoa tsa polymer tse sebetsang, lisebelisoa tsa fluorescent, joalo-joalo, ka lebaka la bokhoni ba eona ba ho hlahisa chlorine, liathomo tsa fluorine le pyridine ka nepo, lisebelisoa tse nang le lisebelisoa tse khethehileng tsa motlakase le tsa mahlo. thepa, le ho khothaletsa nts'etsopele ea mahlale a morao-rao joalo ka lisebelisoa tse bohlale le lisebelisoa tsa ponts'o.
