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2-Amino-6-bromopyridine (CAS# 19798-81-3) Setšoantšo se hlahang
  • 2-Amino-6-bromopyridine (CAS# 19798-81-3) 1

2-Amino-6-bromopyridine (CAS# 19798-81-3)

Thepa ea Lik'hemik'hale:

Foromo ea limolek'hule C5H5BrN2
'Misa oa Molar 173.01
Botenya 1.710±0.06 g/cm3(E boletsoeng esale pele)
Melting Point 88-91 °C (hote.)
Boling Point 273.0±20.0 °C(E boletsoeng esale pele)
Flash point 118.9°C
Ho qhibiliha ha Metsi E qhibiliha hanyane ka metsing.
Solubility Chloroform (Hanyenyane), Methanol (Hanyenyane haholo)
Khatello ea Mouoane 0.0059mmHg ho 25°C
Ponahalo Phofo e bosoeu ho isa ho sootho
Mmala E mosehla hanyane ho isa ho sootho
pKa 2.73±0.24(E boletsoeng esale pele)
Boemo ba polokelo Boloka sebakeng se lefifi, se tiisitsoe moo ho omileng, Mocheso oa Kamore

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Kotsi le Polokeho

Likhoutu tsa Kotsi R36/37/38 – Ho tena mahlo, tsamaiso ya ho hema le letlalo.
R20/21/22 – E kotsi ka ho hema, ho kopana le letlalo le ha e koetsoe.
Tlhaloso ea Tšireletseho S26 - Ha u kopana le mahlo, hlatsoa hang-hang ka metsi a mangata 'me u batle keletso ea bongaka.
S36 - Apara liaparo tse loketseng tsa tšireletso.
S36/37/39 - Apara liaparo tse loketseng tsa tšireletso, liatlana le tšireletso ea mahlo / sefahleho.
WGK Jeremane 3
Khoutu ea HS 29333999
Sehlopha sa Likotsi TS'OALANG

 

 

2-Amino-6-bromopyridine (CAS# 19798-81-3) Boitsebiso

Kakaretso 2-amino substituted nitrogen e nang le litho tse tšeletseng tsa heterocyclic metsoako e na le ts'ebeliso ea bohlokoa indastering ea lik'hemik'hale, joalo ka 2-amino -6-Bromopyridine ke e 'ngoe ea meaho ea bohlokoa ho lithethefatsi tsa maiketsetso le limolek'hule tsa lik'hemik'hale tsa temo,' me e sebelisoa haholo ho kopantseng. ea lihlahisoa tsa tlhaho, lithethefatsi, lisebelisoa tse khanyang le lik'hemik'hale tse fapaneng tse ntle.
Kopo 2-amino substituted nitrogen-containing six-membed heterocyclic compounds na le ts'ebeliso ea bohlokoa indastering ea lik'hemik'hale, joalo ka 2-amino -6-Bromopyridine ke e 'ngoe ea likarolo tsa bohlokoa ho lithethefatsi tsa maiketsetso le limolek'hule tsa lik'hemik'hale tsa temo,' me e sebelisoa haholo ho kopanya. ea lihlahisoa tsa tlhaho, lithethefatsi, lisebelisoa tse khanyang le lik'hemik'hale tse fapaneng tse ntle.
Tokisetso Tokisetso ea 2-amino-6-bromopyridine: Eketsa 2-fluoro-6-bromo-pyridine (1mmol), pentamidine hydrochloride (2mmol), sodium tert-butoxide (3mmol), HO(0.5mL) le diethylene glycol dimethyl ether (2.5) mL) ka har'a tube ea 25 ml ea karabelo. Karabelo e ile ea etsoa ka 150 ℃ bakeng sa lihora tse 24. Ka mor'a hore karabelo e phethoe, e ile ea pholile ho fihlela mocheso oa kamore. Eketsa 10mL ea ethyl acetate ho tima karabelo, eketsa 6mL ea metsi a letsoai a tletseng letsoai ho hlatsoa, ​​ho arola karolo ea manyolo, ebe u ntša karolo ea metsi ka ethyl acetate ka makhetlo a 3 (tekanyo ea ethyl acetate nako le nako ke 6mL) 'me u kopanye manyolo. mohato, eketsa anhydrous sodium sulfate ho omella, tlosa solvent ho kenyelletsa le organic solvent le inorganic solvent ka vacuum. distillation, 'me joale arola manyolo solvent ka kholomo chromatography ho fumana shebiloeng sehlahisoa 2-amino-6-bromopyridine ka lihlahisoa 93%.
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