2 4-Difluorobenzoic acid (CAS# 1583-58-0)
Kotsi le Polokeho
| Matšoao a Kotsi | Xi - Ea halefisang |
| Likhoutu tsa Kotsi | 36/37/38 - Ho halefisa mahlo, tsamaiso ea ho hema le letlalo. |
| Tlhaloso ea Tšireletseho | S26 - Ha u kopana le mahlo, hlatsoa hang-hang ka metsi a mangata 'me u batle keletso ea bongaka. S37/39 - Apara liatlana tse loketseng le tšireletso ea mahlo / sefahleho |
| WGK Jeremane | 3 |
| Khoutu ea HS | 29163990 |
| Sehlopha sa Likotsi | TS'OALANG |
Indasteri ea Phahamiso e Tlase
| Lihlahisoa tse tlase | 2,4-Difluorobenzotrifluoride 2,4-DIFLUORO-5-NITROBENZOIC ACID 3-bromo-2,6-difluorobenzoic acid 4-FLUORO-2-METHOXYBENZAMIDE METHYL 4-FLUORO-2-HYDROXYBENZOATE |
Tlhaho
| maemo a polokelo | E tiisitsoe ka ho omme, Mocheso oa Kamore |
| acidity coefficient (pKa) | 3.21±0.10(E boletsoeng esale pele) |
| ho qhibiliha ha metsi | THABELOA |
| BRN | 973355 |
| InChIKey | NJYBIFYEWYWYAN-UHFFFAOYSA-N |
| thepa ea lik'hemik'hale | phofo e tšoeu |
| tshebediso | meriana le metsi a kristale intermediates. |
Lintlha tsa ts'ireletso
| WGK Jeremane | 3 |
| Tsebiso ea Kotsi | E tenang |
| HazardClass | TS'OALANG |
| khoutu ea meetlo | 29163990 |
Lisebelisoa le mekhoa ea ho kopanya
Kopo
2, 4-difluorobenzoic acid ke ea bohlokoa ea lithethefatsi le chefo e bolaeang likokoanyana mahareng, tse kang 2, 4-difluorobenzoic acid e haholo-holo sebelisoa ho synthesize antifungal lithethefatsi fluconazole, voriconazole le chefo e bolaeang likokoanyana lipakeng 4-fluorosalicylic acid, lithethefatsi mahareng 3, 5-difluoro, joalo-joalo. 2, 4-difluorobenzoic acid e ka e boetse e sebelisoa ka thepa ea kristale ea metsi, e nang le melemo ea boleng bo phahameng le tebello e ntle ea 'maraka.
Tokisetso
Kenya 2, 4-dinitrotoluene le metsi sekepeng sa karabelo, fetola boleng ba pH ho 7, tsosa le mocheso ho 75°C. Potassium permanganate, magnesium sulfate le phase transfer catalyst li kentsoe ka lihlopha. Kamora ho eketsa, tsoela pele ho hlohlelletsa le ho itšoara ka mocheso o sa feleng bakeng sa lihora tse 3. Sefa ha ho chesa 'me u hlatsoe kuku e sefang ka metsi a chesang. Kopanya filtrate, acidify le 35% hydrochloric acid ho pH 2-3, ho na le palo e kholo ea precipitates e tšoeu ka mor'a hore likristale li theohe ka ho feletseng, li hloekisoe, li hlatsuoe, li hloekisoe, 'me li omisoe ho fumana likristale tse tšoeu e le 2,4-dinitrobenzoic acid. . Karolelano ea 2, 4-dinitrotoluene ho potasiamo permanganate ke 2.4:1. Sehlahisoa sa sehlahisoa sa mohato ona ke 90.7%.
eketsa N, N-dimethylmethylphthalamide ka har'a setshelo sa karabelo, mocheso ho 100 ~ 110 ℃, preheat bakeng sa 0.5 ~ 1h. Eketsa anhydrous potassium fluoride e omisitsoeng tlas'a ho hlohlelletsa 'me u boloke mocheso o futhumetse bakeng sa 0.5-1h. Ka mor'a moo, 2, 4-dinitrobenzoic acid le hexyltrimethylammonium bromide li ile tsa kenngoa ka potlako sekepeng sa karabelo ka nako e le 'ngoe,' me mocheso o ile oa tsoela pele ho 120 ℃, mocheso o ile oa bolokoa 'me karabelo e susumetsang e tsoela pele. Ka mor'a lihora tse 7 tsa karabelo ea reflux, solvent e tsosolosoa ka distillation, ebe metsi a arabelang a tšeloa ka mouoane. Karolo e bokelitsoeng ke emulsion e tšoeu. Ka mor'a ho ema nako e itseng, karoloana e nang le mafura a mafura e theohela tlaase, ho tšeloa mokelikeli o mosoeu o hlakileng karolong e ka holimo, 'me oli e pholile ho fokotsa likristale tse tšoeu ho fumana sehlahisoa se tala; Sehlahisoa se sa hlakang se entsoe bocha, Sesefa, ho hlatsuoa le ho omisoa ho fumana likristale tse tšoeu tsa 2,4-difluorobenzoic acid. Karolelano ea palo ea 2, 4-dinitrobenzoic acid ho potasiamo fluoride ke 2.7: 1. Sehlahisoa sa sehlahisoa sa mohato ona ke 72.4%.
Selelekela
2,4-Difluorobenzoic acid ke motsoako oa manyolo. Se latelang ke selelekela sa thepa, tšebeliso, mekhoa ea ho lokisa le tlhaiso-leseling ea polokeho ea 2,4-difluorobenzoic acid:
Boleng:
- Ponahalo: 2,4-Difluorobenzoic acid ke kristale e tšoeu e tiileng.
- Sollubility: E qhibiliha ka har'a metsoako e tloaelehileng ea tlhaho e kang ethanol, methanol le methylene chloride.
Sebelisa:
- Lisebelisoa tsa Optical: E ka sebelisoa hape e le e 'ngoe ea lisebelisoa tse tala bakeng sa ho lokisa lisebelisoa tsa optical le lifilimi tsa optical.
- Lisebelisoa tsa indasteri: 2,4-difluorobenzoic acid e ka sebelisoa indastering ea lisebelisoa tsa elektronike, liphahlo le indasteri ea polasetiki e nang le anti-corrosion, anti-oxidation le anti-ultraviolet liphello.
Mokhoa:
- 2,4-Difluorobenzoic acid e ka fumanoa ka fluorination ea hydrofluoric acid e nang le p-methylanisole.
Lintlha tsa Tšireletseho:
- Ha o sebetsa, lerōle le lokela ho qojoa ho qoba ho hema le ho shebana le mahlo. Ka nako e ts'oanang, maemo a matle a moea a lokela ho bolokoa.
- Qoba ho kopana le li-oxidizing tse matla kapa li-acid tse matla ho qoba liketso tse kotsi
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