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2 4-Dichloro-5-methylpyrimidine (CAS# 1780-31-0) Setšoantšo se hlahang
  • 2 4-Dichloro-5-methylpyrimidine (CAS# 1780-31-0) 1

2 4-Dichloro-5-methylpyrimidine (CAS# 1780-31-0)

Thepa ea Lik'hemik'hale:

Foromo ea limolek'hule C5H4Cl2N2
'Misa oa Molar 163
Botenya 1.39 g/mL ho 25 °C (hote.)
Melting Point 26-28 °C (hote.)
Boling Point 108-109 °C/11 mmHg (hote.)
Flash point >230°F
Solubility E qhibiliha ka chloroform, ether, ethyl acetate le toluene
Khatello ea Mouoane 0.079mmHg ho 25°C
Ponahalo phofo ho hlapa ho hlakisa lero
Mmala E tšoeu kapa e se na 'Mala ho ea ho E batla e le tšoeu kapa E batla e se na 'mala
pKa -2.44±0.29(E boletsoeng esale pele)
Boemo ba polokelo Sepakapaka se inehetseng, 2-8°C

Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Kotsi le Polokeho

Matšoao a Kotsi C - E senya
Likhoutu tsa Kotsi 34 - E baka ho chesa
Tlhaloso ea Tšireletseho S26 - Ha u kopana le mahlo, hlatsoa hang-hang ka metsi a mangata 'me u batle keletso ea bongaka.
S36/37/39 - Apara liaparo tse loketseng tsa tšireletso, liatlana le tšireletso ea mahlo / sefahleho.
S45 – Ha ho ka etsahala kotsi kapa ha o ikutlwa o sa phele hantle, batla keletso ya bongaka hanghang (bontsha leibole neng kapa neng ha ho kgoneha.)
S27 - Tlosa hang-hang liaparo tsohle tse silafetseng.
Li-ID tsa UN UN 3261 8/PG 2
WGK Jeremane 3
TSCA Ee
Khoutu ea HS 29335990
Sehlopha sa Likotsi 8
Sehlopha sa ho paka III

2 4-Dichloro-5-methylpyrimidine (CAS# 1780-31-0) Boitsebiso

Sebelisa 2, 4-dichloro-5-methylpyrimidine e ka sebelisoa ho lokisetsa 2-fluoro-5-trifluoromethylpyrimidine. 2-fluoro-5-trifluoromethylpyrimidine ke karolo e bohareng ea bohlokoa bakeng sa ho qaptjoa ha meriana, e ka sebelisetsoang ho kopanya metsoako ea dihydrofuran e kopantsoeng, le metsoako ea li-ring dihydrofuran e kopantsoeng e ka sebelisoa e le li-modulators tsa G protheine receptor GPR119, bakeng sa phekolo ea lefu la tsoekere, botenya le lefu la dyslipidemia. Ho feta moo, 2-fluoro-5-trifluoromethylpyrimidine e ka boela ea sebelisoa e le setsi sa ho kopanya lithethefatsi bakeng sa phekolo ea lefu la Alzheimer le schizophrenia.
tokisetso 5-methyluracil 75g(0.59mol), phosphorus oxychloride 236g, triethylamine hydrochloride 16.5g(0.12mol), e kenyellelitsoe ho flask ea karabelo, e futhumetseng ho 100 ℃ ~ 110 ℃, Reflux reaction 5H, phosphorus chloride 4 ℃ chloride ho eketsa 248(1.19mol), karabelo ea ho boloka mocheso 2H. Kamora ho phethela karabelo, phosphorus oxychloride e ile ea khutlisoa ka distillation tlasa khatello e fokotsehileng, mme distillation tlasa khatello e fokotsehileng e ile ea tsoela pele ho fumana 88g (0.54mol) ea 2, 4-dichloro-5-methylpyrimidine ka lihlahisoa tsa 91.5%.
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